Placenta Previa in the Second Trimester: Sonographic and Clinical Factors Associated with Its Resolution
Open accessAbstract
We identify characteristics that predict resolution of placenta previa and develop a clinical model for likelihood of resolution. We conducted a retrospective study of 366 singleton pregnancies complicated by placenta previa diagnosed with resolution of the previa as the primary outcome. Regression analyses were performed to determine variables associated with resolution and optimal timing for repeat sonographic evaluation. A likelihood of resolution model was created using a parametric survival model with Weibull hazard function. Of the 366 cases, 84% of complete placentae previae and 98% of marginal placentae previae resolved at a mean gestational age of 28.6 ± 5.3 weeks. Only gestational age and distance from the internal cervical os at the time of diagnosis were significantly associated with resolution ( P < 0.01). Likelihood of resolution was not significantly associated with any other variables. Marginal previae diagnosed in the second trimester do not appear to warrant repeat ultrasound evaluation for resolution.
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Apparent placental 'migration' following development of the lower uterine segment during the third trimester results in resolution of the low-lying placenta in 90% of cases before term.
“Apparent placental 'migration' following the development of the lower uterine segment during the third trimester of pregnancy results in the resolution of the low-lying placenta in 90% of the cases before term.[38][39][40][41][42][43][44][45][46]”
From Placenta Praevia and Placenta Accreta: Diagnosis and Management: Green‐top Guideline No. 27a (2019) · cites this paper as [40]
The Results report that 90% of placenta previas had resolved by 34 4/7 weeks, before term. However, that figure covers complete and marginal previas together; 98% of marginal previas resolved. The paper does not attribute resolution to placental “migration” caused by development of the lower uterine segment. (LLM, conf=0.87)
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References 12 · Cited by 37
- Authors
- Eichelberger, K., Haeri, S., Kessler, D., Swartz, A., Herring, A., & Wolfe, H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- American Journal of Perinatology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2011-06-09
- Volume
- 28
- Issue
- 09
- Pages
- 735-740
- ISSN
- 0735-1631 (ISSN-L)
- 1098-8785
- PMC
- PMC3175253
- OpenAlex
- W1997119390
- Cited by
- 37
- References
- 12
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Perinatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences (T32ES007018)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Keywords
- placenta previa, second trimester, complete placenta previa, gestational age, prediction model, Weibull survival model, singleton pregnancy
- MeSH terms
- Female, Gestational Age, Humans, Placenta Previa, Pregnancy, Pregnancy Trimester, Second, Regression Analysis, Remission, Spontaneous, Retrospective Studies, Ultrasonography, Likelihood Functions, Logistic Models
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