DASH Diet, Insulin Resistance, and Serum hs-CRP in Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial
Abstract
This study was designed to assess the effects of Dietary Approaches to Stop Hypertension (DASH) eating plan on insulin resistance and serum hs-CRP in overweight and obese women with PCOS. This randomized controlled clinical trial was done on 48 women diagnosed with PCOS. Subjects were randomly assigned to consume either the control (n=24) or the DASH eating pattern (n=24) for 8 weeks. The DASH diet consisted of 52% carbohydrates, 18% proteins, and 30% total fats. It was designed to be rich in fruits, vegetables, whole grains, and low-fat dairy products and low in saturated fats, cholesterol, refined grains, and sweets. Sodium content of the DASH diet was designed to be less than 2 400 mg/day. The control diet was also designed to contain 52% carbohydrates, 18% protein, and 30% total fat. Fasting blood samples were taken at baseline and after 8 weeks intervention to measure insulin resistance and serum hs-CRP levels. Adherence to the DASH eating pattern, compared to the control diet, resulted in a significant reduction of serum insulin levels (−1.88 vs. 2.89 μIU/ml, p=0.03), HOMA-IR score (−0.45 vs. 0.80; p=0.01), and serum hs-CRP levels (−763.29 vs. 665.95 ng/ml, p=0.009). Additionally, a significant reduction in waist (−5.2 vs. −2.1 cm; p=0.003) and hip circumference (−5.9 vs. −1 cm; p<0.0001) was also seen in the DASH group compared with the control group. In conclusion, consumption of the DASH eating pattern for 8 weeks in overweight and obese women with PCOS resulted in the improvement of insulin resistance, serum hs-CRP levels, and abdominal fat accumulation. Clinical trial registration number: www.irct.ir: IRCT201304235623N6
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Four trials mentioning trial registration were considered to have a low risk of reporting bias.
“Four trials mentioning trial registration (37, 38, 41, 42) were considered to have a low risk of reporting bias (Fig. 2).”
From Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome (2020) · cites this paper as [38]
Several studies demonstrated that the DASH diet had beneficial effects on markers of insulin resistance, inflammation, oxidative stress, and on hormonal profile (reduced androgens, anti-Müllerian hormone).
“In fact, several studies demonstrated that DASH diet had beneficial effect on markers of IR, inflammation, oxidative stress, and on hormonal profile (reduced androgens, anti-Müllerian hormone) [34–37].”
From Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [34]
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References 44 · Cited by 134
- Authors
- Asemi, Z., & Esmaillzadeh, A.
- Affiliations
- Kashan University of Medical Sciences (IR)
- Isfahan University of Medical Sciences (IR)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2014-06-23
- Volume
- 47
- Issue
- 03
- Pages
- 232-238
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2084203199
- Cited by
- 134
- References
- 44
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 10 · 2023: 14 · 2022: 9 · 2021: 27 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 12 · 2016: 7 · 2015: 5 · 2014: 2
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kashan University of Medical Sciences
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- DASH diet, polycystic ovary syndrome, insulin resistance, high-sensitivity C-reactive protein, obesity, overweight women, dietary intervention, HOMA-IR, waist circumference, abdominal fat, inflammation
- MeSH terms
- Adult, C-Reactive Protein, Diet, Female, Humans, Insulin, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Overweight, Young Adult
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