MCT8 is downregulated by short time iodine overload in the thyroid gland of rats
Abstract
Wolff-Chaikoff effect is characterized by the blockade of thyroid hormone synthesis and secretion due to iodine overload. However, the regulation of monocarboxylate transporter 8 during Wolff-Chaikoff effect and its possible role in the rapid reduction of T4 secretion by the thyroid gland remains unclear. Patients with monocarboxylate transporter 8 gene loss-of-function mutations and monocarboxylate transporter 8 knockout mice were shown to have decreased serum T4 levels, indicating that monocarboxylate transporter 8 could be involved in the secretion of thyroid hormones from the thyroid gland. Herein, we aimed to evaluate the regulation of monocarboxylate transporter 8 during the Wolff-Chaikoff effect and the escape from iodine overload, besides the importance of iodine organification for this regulation. Monocarboxylate transporter 8 mRNA and protein levels significantly decreased after 1 day of NaI administration to rats, together with decreased serum T4; while no alteration was observed in LAT2 expression. Moreover, both monocarboxylate transporter 8 expression and serum T4 was restored after 6 days of NaI. The inhibition of thyroperoxidase activity by methimazole prevented the inhibitory effect of NaI on thyroid monocarboxylate transporter 8 expression, suggesting that an active thyroperoxidase is necessary for MCT8 downregulation by iodine overload, similarly to other thyroid markers, such as sodium iodide symporter. Therefore, we conclude that thyroid monocarboxylate t…
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MCT8 favors T4 secretion over T3 secretion, as demonstrated by the higher-than-normal T3/T4 ratio in MCT8 KO mice and in patients with MCT8 mutation.
“MCT8 favors T4 secretion over T3 secretion, as demonstrated by the higher-than-normal T3/T4 ratio in MCT8 KO mice and in patients with MCT8 mutation (101, 102).”
From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [102]
Iodide overload decreases MCT8 mRNA and protein expression in rats, thus reducing T4 and T3 secretion into the blood stream.
“Lastly, iodide overload decreased MCT8 mRNA and protein expression in rats, thus reducing T4 and T3 secretion into the blood stream (102, 215).”
From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [102]
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- Authors
- de Souza, E., Dias, G., Cardoso, R., Lima, L., Fortunato, R., Visser, T., Vaisman, M., Ferreira, A., & Carvalho, D.
- Affiliations
- Laboratory of Endocrine Physiology Doris Rosenthal, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
- Universidade Federal do Rio de Janeiro (BR)
- Erasmus MC (NL)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2015-05-28
- Volume
- 47
- Issue
- 12
- Pages
- 910-915
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2473554051
- Cited by
- 23
- References
- 0
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 1
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- MCT8, Wolff-Chaikoff effect, iodine excess, thyroid hormone secretion, thyroxine, thyroid peroxidase, LAT2, sodium iodide symporter, thyroid gland, methimazole, iodide
- MeSH terms
- Animals, Iodine, Male, Thyroid Gland, Thyroid Hormones, Down-Regulation, Rats, Wistar, Amino Acid Transport System y+, Fusion Regulatory Protein 1, Light Chains, Monocarboxylic Acid Transporters, Rats
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