The DOI matches its Crossref record.
Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention—An Update
Abstract
Although genetic susceptibility explains the clustering of multiple sclerosis (MS) within families and the sharp decline in risk with increasing genetic distance, it cannot fully explain the geographical variations in MS frequency and the changes in risk that occur with migration, which support the action of strong environmental factors. Among these, vitamin D status, obesity in early life, infection with the Epstein-Barr virus, and cigarette smoking are the most consistent environmental predictors of MS risk. The authors review the epidemiological data, critically discuss the evidence for causality of these and other associations, and briefly review the possibility of interventions to reduce MS risk.
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Cited by
Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491
Bjornevik, K., Cortese, M., Healy, B. C., Kuhle, J., Mina, M. J., Leng, Y., Elledge, S. J., Niebuhr, D. W., Scher, A. I., Munger, K. L., et al. (2022) · Science · doi:10.1126/science.abj8222 · Cited by 2,049
Self-citationFilippi, M., Bar-Or, A., Piehl, F., Preziosa, P., Solari, A., Vukusic, S., & Rocca, M. A. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0041-4 · Cited by 1,562
Multiple sclerosis: experimental models and reality
Lassmann, H., & Bradl, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1631-4 · Cited by 525
Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications
Bjornevik, K., Münz, C., Cohen, J. I., & Ascherio, A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00775-5 · Cited by 246
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Metadata
- Authors
- Munger, K., & Ascherio, A.
- Venue
- Seminars in Neurology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2016-04-26
- Volume
- 36
- Issue
- 02
- Pages
- 103-114
- ISSN
- 0271-8235 (ISSN-L)
- 1098-9021
- OpenAlex
- W2344951985
- Cited by
- 314
- References
- 0
- FWCI
- 19.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Munger, K., & Ascherio, A. (2016). Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention—An Update. Seminars in Neurology. https://doi.org/10.1055/s-0036-1579693
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
