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Neuroimaging in Dementia
Open accessAbstract
Although the diagnosis of dementia still is primarily based on clinical criteria, neuroimaging is playing an increasingly important role. This is in large part due to advances in techniques that can assist with discriminating between different syndromes. Magnetic resonance imaging remains at the core of differential diagnosis, with specific patterns of cortical and subcortical changes having diagnostic significance. Recent developments in molecular PET imaging techniques have opened the door for not only antemortem but early, even preclinical, diagnosis of underlying pathology. This is vital, as treatment trials are underway for pharmacological agents with specific molecular targets, and numerous failed trials suggest that earlier treatment is needed. This article provides an overview of classic neuroimaging findings as well as new and cutting-edge research techniques that assist with clinical diagnosis of a range of dementia syndromes, with an emphasis on studies using pathologically proven cases.
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“Positron emission tomography has been employed to visualize Aβ plaques in the brain for the diagnosis of AD, 3 however it has obvious shortcomings, such as radioligand use, limited spatial resolution and higher cost.4”
From Amyloid Plaque Imaging with a Targeted MRI Contrast Agent in a Transgenic Mouse Model of Alzheimer’s Disease (2022) · cites this paper as [3]
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Self-citationLongitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials
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Metadata
- Authors
- Staffaroni, A., Elahi, F., McDermott, D., Marton, K., Karageorgiou, E., Sacco, S., Paoletti, M., Caverzasi, E., Hess, C., Rosen, H., & Geschwind, M.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Geschwind, Michael
- ORCID
- Venue
- Seminars in Neurology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2017-10
- Volume
- 37
- Issue
- 05
- Pages
- 510-537
- ISSN
- 0271-8235 (ISSN-L)
- 1098-9021
- PMC
- PMC5823524
- OpenAlex
- W4241885035
- Cited by
- 91
- References
- 377
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 9 · 2023: 21 · 2022: 17 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 9
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Seminars in Neurology (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (R01AG032306, K24AG045333, T32AG023481)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- dementia, neuroimaging, differential diagnosis, magnetic resonance imaging, preclinical diagnosis, dementia syndromes, treatment trials
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