A Chromogenic Assay Allows Reliable Measurement of Factor VIII Levels in the Presence of Strong Lupus Anticoagulants
Abstract
A Chromogenic Assay Allows Reliable Measurement of Factor VIII Levels in the Presence of Strong Lupus Anticoagulants -
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Chromogenic factor assays (CSA) do not suffer from these interferences, showing normal clotting factor activities.
“A fundamental aid in these circumstances comes from performing chromogenic factor assays (CSA) [90], which do not suffer from these interferences, showing normal clotting factor activities [92,96,97].”
From Lupus Anticoagulant Detection under the Magnifying Glass (2023) · cites this paper as [92]
Other coagulation assays that use aPTT-based methods may show interference due to LA presence, resulting in falsely low factor activity.
“Other coagulation assays that use aPTT-based methods, as one stage measurement (OSA) [90] for factors VIII, IX, XI, and XII, may show interference due to LA presence, resulting in falsely low factor activity [91,92,93,94,95,96,97,98].”
From Lupus Anticoagulant Detection under the Magnifying Glass (2023) · cites this paper as [92]
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Lupus Anticoagulant Detection under the Magnifying Glass
Molinari, A. C., Martini, T., Banov, L., Ierardi, A., Leotta, M., Strangio, A., & Santoro, R. C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206654 · Cited by 9 · see citing works
Patil, R., S., C., Parihar, A., Mohite, A., & Shetty, S. (2018) · Thrombosis Research · doi:10.1016/j.thromres.2018.10.015 · Cited by 2 · see citing works
- Authors
- Wahl, D., Perret-Guillaume, C., Regnault, V., Clarac, S., Briquel, M.-E., Andre, E., Lecompte, T., & de Maistre, E.
- Affiliations
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1998
- Volume
- 79
- Issue
- 01
- Pages
- 237-238
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W1854248427
- Cited by
- 42
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hemophilia Treatment and Research
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- factor VIII, lupus anticoagulant, chromogenic assay, coagulation factor measurement, assay interference, anticoagulant screening
- MeSH terms
- Blood Coagulation Tests, Chromogenic Compounds, Factor VIII, Humans, Reproducibility of Results, Lupus Coagulation Inhibitor
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