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The Relationship of Antiphospholipid Antibodies to Thromboembolic Disease in Systemic Lupus Erythematosus: A Cross-Sectional Study
Abstract
In order to determine whether an association exists between antiphospholipid antibodies (APLA) and thromboembolic events in patients with systemic lupus erythematosus (SLE), we performed a cross-sectional study of consecutive unselected SLE patients. The occurrence of previous thromboembolic events was determined by investigators blinded to the APLA status of the patients by critical review of objective tests that had been performed at the time of symptomatic presentation and by performing venous Doppler ultrasound of the legs to elicit venous reflux as an indication of previous venous thrombosis. The presence of APLA was determined by coagulation assays for the lupus anticoagulant (LA) using five tests with well-defined control ranges and by ELISA assay for anticardiolipin antibodies (ACLA). These tests were measured on two separate occasions. The results of the study demonstrate a statistically significant association between persistently abnormal ACLA assays and thromboembolic events and a non-significant trend between persistently abnormal LA and thromboembolic events. Transient abnormalities of LA and ACLA were less strongly associated with thromboembolic events. We conclude that in patients with SLE, there is a significant association between thromboembolism and APLA.
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“Even in the absence of antiphospholipid antibodies, patients with SLE have an increased risk of thromboembolic events.3”
From Evaluation of different ways to identify persistent positivity of lupus anticoagulant in systemic lupus erythematosus (2020) · cites this paper as [3]
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Venous Thromboembolism, Thrombophilia, Antithrombotic Therapy, and Pregnancy
Bates, S. M., Greer, I. A., Pabinger, I., Sofaer, S., & Hirsh, J. (2008) · CHEST Journal · doi:10.1378/chest.08-0761 · Cited by 790
Self-citationUse of Antithrombotic Agents During Pregnancy
Ginsberg, J. S., & Hirsh, J. (1995) · CHEST Journal · doi:10.1378/chest.108.4_supplement.305s · Cited by 660
Self-citationUse of Antithrombotic Agents During Pregnancy
Bates, S. M., Greer, I. A., Hirsh, J., & Ginsberg, J. S. (2004) · CHEST Journal · doi:10.1378/chest.126.3_suppl.627s · Cited by 550
Self-citationSchulman, S., Svenungsson, E., & Granqvist, S. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00060-6 · Cited by 497
Management of Antiphospholipid Antibody Syndrome
Lim, W., Crowther, M. A., & Eikelboom, J. W. (2006) · JAMA · doi:10.1001/jama.295.9.1050 · Cited by 441
“Depending on the assay, antiphospholipid antibodies are reported in up to 10% of healthy individuals and in 30% to 50% of patients with SLE.(6) Antiphospholipid antibodies are more common in patients with thrombosis but a causal association is unproven and the clinical relevance of transient or low titer antiphospholi…”
BackgroundInfluential
Metadata
- Authors
- Long, A. A., Ginsberg, J. S., Brill-Edwards, P., Johnston, M., Turner, C., Denburg, J. A., Bensen, W. G., Cividino, A., Andrew, M., & Hirsh, J.
- Affiliations
- McMaster University (CA)
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1991
- Volume
- 66
- Issue
- 05
- Pages
- 520-524
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2462341569
- Cited by
- 120
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 1 · 2013: 7 · 2012: 2
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- antiphospholipid antibodies, systemic lupus erythematosus, thromboembolism, lupus anticoagulant, anticardiolipin antibodies, venous thrombosis, venous Doppler ultrasound, thrombosis risk factors
- MeSH terms
- Autoantibodies, Blood Coagulation Tests, Humans, Lupus Erythematosus, Systemic, Partial Thromboplastin Time, Phospholipids, Thromboembolism, Factor Xa
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