Aging and the Biological Response to Liver Injury
Abstract
Interest in understanding the aging process has recently risen in the scientific community. Aging, commonly defined as the functional decline in the function of organs and tissues, is indeed the major risk factor for the development of many chronic diseases, such as cardiovascular diseases, pathologies of nervous system, or cancer. To date, the influence of aging in the pathophysiology of liver and biliary diseases is not fully understood. Although liver cells have a high regenerative capacity, hepatocytes and cholangiocytes undergo extensive molecular changes in response to aging. Following time-dependent damage induced by aging, liver cells initially activate compensatory mechanisms that, if hyperstimulated, may lead to the decline of regenerative capacity and the development of pathologies. A deeper understanding of molecular aging has undoubtedly the potential to improve the clinical management of patients, possibly unveiling new pathways for selective drug treatment.
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Liver cells initially activate compensatory mechanisms in response to time-dependent damage caused by aging, which can lead to liver pathologies if overstimulated.
“Liver cells initially activate compensatory mechanisms in response to time-dependent damage caused by aging, which can lead to the development of pathologies of the liver if overstimulated.153”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [153]
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References 123 · Cited by 36
- Authors
- Marzioni, M., Pinto, C., Ninfole, E., Gaggiano, L., Benedetti, A., & Maroni, L.
- Affiliations
- Marche Polytechnic University (IT)
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 2019-12-30
- Volume
- 40
- Issue
- 03
- Pages
- 225-232
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- OpenAlex
- W2997198647
- Cited by
- 36
- References
- 123
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 8 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- aging, liver injury, hepatocyte regeneration, cholangiocytes, compensatory mechanisms, liver disease, biliary tract diseases, molecular aging, chronic disease risk, hepatocyte senescence
- MeSH terms
- Aging, Animals, Biliary Tract Diseases, Humans, Liver, Liver Diseases, Disease Progression
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