The role of adenomyosis in the pathogenesis of preeclampsia
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INTRODUCTION: Adenomyosis can cause defective deep placentation. Preeclampsia is known to be associated with abnormal placentation. The aim of this study was to compare the presence of adenomyosis on magnetic resonance imaging in patients with and without history of preeclampsia in order to investigate the possible role of adenomyosis in the pathogenesis of preeclampsia. MATERIALS AND METHODS: This prospective, randomized study consisted of patients with (n = 35) and without (n = 34) history of preeclampsia. Direct (submucosal microcysts, adenomyoma and cystic adenomyoma) and indirect (maximal thickness of junctional zone, ratio of maximal thickness of junctional zone to myometrial thickness, junctional zone differential, focal thickening of junctional zone, globally enlarged uterus and non-uniform junctional zone contours) signs of adenomyosis were assessed by pelvic magnetic resonance imaging. RESULTS: The prevalence of adenomyosis was found to be more common in patients with preeclampsia und fetal growth restriction compared to patients without fetal growth restriction (94.4 vs. 64.7 %; p = 0.041), respectively. There was a strong association between maximal thickness of junctional zone (9 vs. 13 mm, p = 0.005), ratio of maximal thickness of junctional zone to myometrial thickness (0.42 vs. 0.66, p = 0.001) and junctional zone differential (3 vs. 5 mm, p = 0.02) and late-onset preeclampsia. CONCLUSIONS: Presence of adenomyoma is more common in patients with preeclampsia complicated with fetal growth restriction. Indirect signs of adenomyosis detected on pelvic magnetic resonance imaging might have a role in the pathogenesis of late-onset preeclampsia.
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Endometriosis, especially cystic ovarian and deep endometriosis, and adenomyosis are associated with abnormal placentation, insufficient physiologic changes in the spiral arteries, and an increased risk of preterm birth, small for gestational age babies, and preeclampsia.
“Endometriosis, especially cystic ovarian and deep endometriosis (130, 131), and adenomyosis (132, 133) are associated with abnormal placentation, insufficient physiologic changes in the spiral arteries, and an increased risk of preterm birth, small for gestational age (SGA) babies, and preeclampsia (131).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [132]
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References 32 · Cited by 18
Research works printed but not linked: 1
- Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1972; 1: 177- 191
- Authors
- Hasdemir, P., Farasat, M., Aydin, C., Ozyurt, B., Guvenal, T., & Pekindil, G.
- Affiliations
- Manisa Celal Bayar University (TR)
- Department of Radiology, Celal Bayar University Medical School, Manisa, Turkey
- Department of Obstetrics and Gynecology, Celal Bayar University Medical School, Manisa, Turkey
- Venue
- Geburtshilfe und Frauenheilkunde
- Publisher
- Georg Thieme Verlag KG
- Published
- 2016-08-25
- Volume
- 76
- Issue
- 08
- Pages
- 882-887
- ISSN
- 0016-5751 (ISSN-L)
- 1438-8804
- PMC
- PMC5000813
- OpenAlex
- W2516920607
- Cited by
- 18
- References
- 32
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1
- FWCI
- 3.01
- Type
- journal article
- Language
- de
- Open access
- bronze
- doi.org
- Locations
- Geburtshilfe und Frauenheilkunde (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- adenomyosis, preeclampsia, late-onset preeclampsia, fetal growth restriction, abnormal placentation, junctional zone, adenomyoma, pelvic MRI, pathogenesis
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