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Cited by 139Adrenal Hormones and DisordersStress Responses and CortisolProtein Interaction Studies and Fluorescence Analysis

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Corticosteroid-Binding Globulin: A Review of Basic and Clinical Advances

Meyer, E., Nenke, M., Rankin, W., Lewis, J., Torpy, D.·2016·Hormone and Metabolic Research
DOI 10.1055/s-0042-108071
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Abstract

Corticosteroid-binding globulin (CBG, transcortin) is the primary cortisol binding protein. It is a non-inhibitory serine protease inhibitor, capable of conformational change from a high cortisol-binding affinity form to a low affinity form upon cleavage of its reactive centre loop by various proteases, such as neutrophil elastase. The burgeoning inflammatory role of CBG applies to acute, severe inflammation where depletion is associated with mortality, and to chronic inflammation where defects in cortisol delivery may perpetuate inflammation. Naturally occurring human mutations influence a wide range of CBG properties and point toward a role in hitherto unexplained chronic musculoskeletal pain and fatigue disorders as well as potentially affecting fertility outcomes including offspring gender. In vitro and knock-out animal models of CBG propose a role for CBG in cortisol transport to the brain, providing a foundation for understanding the human observations in those with CBG mutations and sex differences in stress-related mood and behaviour. Finally, CBG measurement has a practical role in the estimation of free cortisol, useful in clinical circumstances where CBG levels or cortisol binding affinity is reduced. Taken together, novel data suggest a role for cortisol in targeted cortisol delivery, with implications in acute and chronic inflammation, as well as roles in metabolism and neurocognitive function, implying that CBG is a multifaceted component in the mechanisms of hypothalamic-pituitary-adrenal axis related homeostasis.

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Metadata

Authors
Meyer, E., Nenke, M., Rankin, W., Lewis, J., & Torpy, D.
Affiliations
  • Royal Adelaide Hospital (AU)
  • South Australia Pathology (AU)
  • Canterbury Health Laboratories (NZ)
Corresponding author
Meyer, E.
ORCID
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
2016-05-23
Volume
48
Issue
06
Pages
359-371
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-0042-108071
OpenAlex
W2408046298
Cited by
139
References
0
Citations by year
2026: 6 · 2025: 17 · 2024: 12 · 2023: 20 · 2022: 9 · 2021: 29 · 2020: 17 · 2019: 6 · 2018: 11 · 2017: 9 · 2016: 3
FWCI
9.68
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Keywords
corticosteroid-binding globulin, cortisol binding, serine protease inhibitors, reactive center loop, neutrophil elastase, chronic inflammation, acute inflammation, hypothalamic-pituitary-adrenal axis, chronic musculoskeletal pain, fertility, sex differences in stress, neurocognitive function
MeSH terms
Animals, Disease, Disease Models, Animal, Humans, Models, Biological, Mutation, Transcortin, Drug Delivery Systems

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