Differential Effects of Trimipramine and Fluoxetine on Sleep in Geriatric Depression
Abstract
The effects of trimipramine, a tricyclic antidepressant (TCA) with atypical pharmacological properties, and fluoxetine, a selective serotonine reuptake inhibitor (SSRI), were compared in an exploratory analysis using mood and polysomnographic parameters during a six-week double-blind trial in 19 depressed geriatric patients. In sleep EEG measures, trimipramine demonstrated clear-cut effects on sleep measures resulting in higher values for sleep efficiency, total sleep time, stage 2 sleep, and shorter wake time. Under fluoxetine treatment, the proportion of REM sleep was decreased and REM latency was lengthened, whereas no change in REM sleep parameters was observed in the trimipramine group. The present data suggest that early antidepressant effects of medication occur independently of drug-induced changes in objective measures of sleep, i.e. suppression of REM sleep.
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Trimipramine (150mg) was associated with improved sleep efficiency, longer sleep, and fewer nocturnal arousals, compared to fluoxetine (20mg), in depressed patients.
“(Wolf et al., 2001) showed that trimipramine (150mg) was associated with improved sleep efficiency, longer sleep, and fewer nocturnal arousals, compared to fluoxetine (20mg).”
From Antidepressants and their effect on sleep (2005) · cites this paper as Wolf et al., 2001
Fluoxetine (20mg) was associated with less efficient, shorter and more disrupted sleep than trimipramine (150mg); fluoxetine suppressed REM sleep, whereas trimipramine did not.
“(Wolf et al., 2001) demonstrated that fluoxetine (20mg) was associated with less efficient, shorter and more disrupted sleep than trimipramine (150mg); fluoxetine suppressed REM sleep, whereas trimipramine did not.”
From Antidepressants and their effect on sleep (2005) · cites this paper as Wolf et al., 2001
EEG studies suggest that sleep length and efficiency are increased, and nocturnal disturbances reduced, for amitriptyline, clomipramine, trimipramine, nortriptyline and doxepin.
“EEG studies suggest that sleep length and efficiency are increased, and nocturnal disturbances reduced, for amitriptyline (Casper et al., 1994), clomipramine (Eberhard et al., 1988), trimipramine (Wolf et al., 2001), nortriptyline (Reynolds, III et al., 1997) and doxepin (Hajak et al., 1996)”
From Antidepressants and their effect on sleep (2005) · cites this paper as Wolf et al., 2001
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Antidepressants and their effect on sleep
Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323 · see citing works
Sleep and Antidepressant Treatment
Wichniak, A., Wierzbicka, A., & Jernajczyk, W. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523608 · Cited by 142 · see citing works
- Authors
- Wolf, R., Dykierek, P., Gattaz, W. F., Maras, A., Kohnen, R., Dittmann, R. W., Geuppert, M., Riemann, D., & Berger, M.
- Affiliations
- University of Freiburg (DE)
- Central Institute of Mental Health (DE)
- Eli Lilly (Germany) (DE)
- Venue
- Pharmacopsychiatry
- Publisher
- Georg Thieme Verlag KG
- Published
- 2001-03
- Volume
- 34
- Issue
- 2
- Pages
- 60-65
- ISSN
- 0176-3679 (ISSN-L)
- 1439-0795
- OpenAlex
- W2059690538
- Cited by
- 25
- References
- 0
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacopsychiatry (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- Lilly Deutschland
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- trimipramine, fluoxetine, geriatric depression, sleep, REM sleep suppression, REM latency, polysomnography, tricyclic antidepressants, selective serotonin reuptake inhibitors, antidepressant effects, sleep efficiency, stage 2 sleep
- MeSH terms
- Affect, Aged, Antidepressive Agents, Tricyclic, Depressive Disorder, Double-Blind Method, Female, Fluoxetine, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep, Sleep Stages, Sleep, REM, Trimipramine, Polysomnography, Antidepressive Agents, Second-Generation
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