The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Pathophysiology of Acute Lung Injury and the Acute Respiratory Distress Syndrome
Abstract
Since the adult respiratory distress syndrome was first described substantial progress has been made in understanding the pathogenesis of this complex syndrome. This review summarizes our current understanding of the pathophysiology of what is now termed the acute respiratory distress syndrome (ARDS) and its less severe form acute lung injury (ALI), with an emphasis on cellular and molecular mechanisms of injury that may represent potential therapeutic targets. Although it is difficult to synthesize all of these abnormalities into a single, unified, pathogenetic pathway, a theme that emerges repeatedly is that of imbalance, be it between pro- and anti-inflammatory cytokines, oxidants and antioxidants, procoagulants and anticoagulants, neutrophil recruitment and activation and mechanisms of neutrophil clearance, or proteases and protease inhibitors. Future therapies aimed at restoring the overall balance of cytokines, oxidants, coagulants, and proteases may ultimately be successful where therapies that target individual cytokines or other mediators have not.
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Cites
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Cited by
Contribution of Neutrophils to Acute Lung Injury
Grommes, J., & Soehnlein, O. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00138 · Cited by 1,313
More friend than foe: the emerging role of neutrophils in tissue repair
Peiseler, M., & Kubes, P. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124616 · Cited by 423
Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies
Iyer, S. S., & Rojas, M. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.5.569 · Cited by 269
Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression
Galam, L., Rajan, A., Failla, A., Soundararajan, R., Lockey, R. F., & Kolliputi, N. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00417.2015 · Cited by 52
Metadata
- Authors
- Ware, L.
- Venue
- Seminars in Respiratory and Critical Care Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2006-08
- Volume
- 27
- Issue
- 4
- Pages
- 337-349
- ISSN
- 1069-3424 (ISSN-L)
- 1098-9048
- OpenAlex
- W2071775013
- Cited by
- 493
- References
- 127
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
