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Niaziminin, a Thiocarbamate from the Leaves of Moringa oleifera, Holds a Strict Structural Requirement for Inhibition of Tumor-Promoter-Induced Epstein-Barr Virus Activation
Abstract
Three known thiocarbamate (TC)- and isothiocyanate (ITC)-related compounds have been isolated from the leaves of Moringa oleifera, a traditional herb in southeast Asia, as inhibitors of tumor promoter teleocidin B-4-induced Epstein-Barr virus (EBV) activation in Raji cells. Interestingly, only niaziminin among 10 TCs including 8 synthetic ones showed considerable inhibition against EBV activation. The structure-activity relationships indicated that the presence of an acetoxy group at the 4'-position of niaziminin is important and indispensable for inhibition. On the other hand, among the ITC-related compounds, naturally occurring 4-[(4'-O-acetyl-alpha-L-rhamnosyloxy)benzyl]ITC and commercially available allyl- and benzyl-ITC significantly inhibited activation, suggesting that the isothiocyano group is a critical structural factor for activity.
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Cited by
Moringa oleifera : a food plant with multiple medicinal uses
Anwar, F., Latif, S., Ashraf, M., & Gilani, A. H. (2007) · Phytotherapy Research · doi:10.1002/ptr.2023 · Cited by 1,657
In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves
Verma, A. R., Vijayakumar, M., Mathela, C. S., & Rao, C. V. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.06.005 · Cited by 498
Bennett, R. N., Mellon, F. A., Foidl, N., Pratt, J. H., Dupont, M. S., Perkins, L., & Kroon, P. A. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0211480 · Cited by 444
Singh, B. N., Singh, B. R., Singh, R. L., Prakash, D., Dhakarey, R., Upadhyay, G., & Singh, H. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.01.034 · Cited by 425
Metadata
- Authors
- Murakami, A., Kitazono, Y., Jiwajinda, S., Koshimizu, K., & Ohigashi, H.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1998-05
- Volume
- 64
- Issue
- 04
- Pages
- 319-323
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1970314789
- Cited by
- 184
- References
- 0
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Niaziminin, a Thiocarbamate from the Leaves of Moringa oleifera, Holds a Strict Structural Requirement for Inhibition of Tumor-Promoter-Induced Epstein-Barr Virus Activation. https://app.cochat.ai/papers/10.1055/s-2006-957442
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- Murakami, A., Kitazono, Y., Jiwajinda, S., Koshimizu, K., & Ohigashi, H. (1998). Niaziminin, a Thiocarbamate from the Leaves of Moringa oleifera, Holds a Strict Structural Requirement for Inhibition of Tumor-Promoter-Induced Epstein-Barr Virus Activation. Planta Medica. https://doi.org/10.1055/s-2006-957442
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