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Anti-Oxidant Activity of Dibenzocyclooctene Lignans Isolated from Schisandraceae
Abstract
The anti-oxidant activity of nine dibenzocyclooctene lignans isolated from Schisandra chinensis, S. rubriflora, and Kadsura longipedunculata, respectively, was studied. Seven of the 9 lignans (1 mM) inhibited iron/cysteine-induced lipid peroxidation (malondialdehyde, MDA, formation) of rat liver microsomes as well as superoxide anion production in the xanthine/xanthine oxidase system. The actions of the 7 lignans were much more potent than vitamin E at the same concentration of 1 mM. Among the lignans, schisanhenol was the most active one. This compound also prevented the decrease of membrane fluidity of liver microsomes induced by iron/cysteine. The results indicated that seven of the lignans such as schisanhenol have anti-oxidant activities.
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Cited by
Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine
Panossian, A., & Wikman, G. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.04.020 · Cited by 522
Schisandra chinensis (Turcz.) Baill
Hancke, J. L., Burgos, R. A., & Ahumada, F. (1999) · Fitoterapia · doi:10.1016/s0367-326x(99)00102-1 · Cited by 296
Analysis of Schisandra chinensis and Schisandra sphenanthera
Lu, Y., & Chen, D.-F. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.09.070 · Cited by 249
Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of action
Panossian, A., Wikman, G., & Wagner, H. (1999) · Phytomedicine · doi:10.1016/s0944-7113(99)80023-3 · Cited by 211
Antioxidant Activity of Ecdysteroids from Serratula strangulata
Dai, J., Cai, Y., Shi, Y., Zhang, Y., Liu, Z., Yang, L., & Li, Y. (2002) · Chinese Journal of Chemistry · doi:10.1002/cjoc.20020200516 · Cited by 15
Metadata
- Authors
- Lu, H., & Liu, G.-T.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1992-08
- Volume
- 58
- Issue
- 04
- Pages
- 311-313
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2029586353
- Cited by
- 159
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lu, H., & Liu, G.-T. (1992). Anti-Oxidant Activity of Dibenzocyclooctene Lignans Isolated from Schisandraceae. Planta Medica. https://doi.org/10.1055/s-2006-961473
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