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Intrahepatic Cholestasis of Pregnancy: An Estrogen-Related Disease
Abstract
In the recent years new avenues have been opened in the treatment of ICP, a complex disorder that seems to represent a maladaptation of some young and otherwise healthy women, to estrogens or other sex hormones. New drugs have been shown capable of providing promising therapeutic effects either on pruritus, the main distressing symptoms of cholestasis (such as epomediol, silymarin) or both on pruritus and some biochemical abnormalities (such as UDCA). Future clinical and experimental studies should provide better insight into the pathogenesis of cholestasis, the mechanisms of bile formation and secretion, and the metabolism of estrogens and other sex hormones and their alteration relationship to cholestasis, a disorder that is highly prevalent in humans.
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Cited by
Intrahepatic cholestasis of pregnancy: A French prospective study
Bacq, Y., Sapey, T., Brechot, M., Pierre, F., Fignon, A., & Dubois, F. (1997) · Hepatology · doi:10.1002/hep.510260216 · Cited by 329
Pauli-Magnus, C., Lang, T., Meier, Y., Zodan-Marin, T., Jung, D., Breymann, C., Zimmermann, R., Kenngott, S., Beuers, U., Reichel, C., et al. (2004) · Pharmacogenetics · doi:10.1097/00008571-200402000-00003 · Cited by 273
Presence of antimitochondrial autoantibodies in patients with autoimmune hepatitis
Nezu, S., Tanaka, A., Yasui, H., Imamura, M., Nakajima, H., Ishida, H., & Takahashi, S. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04434.x · Cited by 52
Alallam, A., Barth, D., & Heathcote, E. J. (2008) · Canadian Journal of Gastroenterology · doi:10.1155/2008/969826 · Cited by 52
Metadata
- Authors
- Reyes, H., & Simon, F.
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 1993-08
- Volume
- 13
- Issue
- 03
- Pages
- 289-300
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- OpenAlex
- W2093776526
- Cited by
- 188
- References
- 0
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reyes, H., & Simon, F. (1993). Intrahepatic Cholestasis of Pregnancy: An Estrogen-Related Disease. Seminars in Liver Disease. https://doi.org/10.1055/s-2007-1007357
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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