The DOI matches its Crossref record; 8 of the 14 references it cites were found in a registry or an index.
Pathophysiology and Epidemiology of Chronic Mountain Sickness
Open accessAbstract
Chronic mountain sickness, which affects permanent residents of high altitudes, is the outcome of a progressive loss of ventilatory rate which naturally occurs with age and resulting in excessive hypoxemia and polycythemia. A theoretical model predicts the progressive failure of homeostatic control of the hemoglobin concentration when the values increase above those found at sea level. This is confirmed by lack of feedback mechanism between high altitude erythrocytosis and serum erythropoietin. The results of epidemiological studies are in agreement with the physiological findings. In a male population living at 4,300 m, an increase with age of the prevalences of excessive erythrocytosis (Hb > 213 g/l), blood oxygen saturation < 83%, headaches and a high score of symptoms of chronic mountain sickness has been found. The studies suggest the possibility that in addition to an accentuated hypoxemia, the excessive erythrocytosis may also result from an overreaction of the bone marrow to a fixed level of hypoxemia in ageing individuals.
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Respiratory insensitivity to hypoxia in chronically hypoxic man.
Severinghaus, J., Bainton, C. R., & Carcelén, A. (1966) · Respiration Physiology · doi:10.1016/0034-5687(66)90049-1 · Cited by 282
HYPOXIA, POLYCYTHEMIA, AND CHRONIC MOUNTAIN SICKNESS
La, J. B. W. (1988) · doi:10.1016/s0012-3692(16)39971-8 · Cited by 160
Different hematologic responses to hypoxia in Sherpas and Quechua Indians
Winslow, R. M., Chapman, K. W., Gibson, C. C., Samaja, M., Monge, C., Goldwasser, E., SHERPA, M. T., Blume, F. D., & Raimundo Santolaya, C. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.4.1561 · Cited by 160
Kryger, M., Glas, R., Jackson, D., et al. (1978) · Sleep · doi:10.1093/sleep/1.1.3 · Cited by 88
High prevalence of migraine in a high‐altitude population
Arregui, A., Cabrera, J., Lèon-Velarde, F., et al. (1991) · Neurology · doi:10.1212/wnl.41.10.1668 · Cited by 79
Self-citationAge as a cause of chronic mountain sickness (Monge's disease)
Sime, F., Monge, C., & Whittembury, J. (1975) · International Journal of Biometeorology · doi:10.1007/bf01463864 · Cited by 56
Monge, C., Lozano, R., & Carcelén, A. (1964) · Journal of Clinical Investigation · doi:10.1172/jci105104 · Cited by 20
Regulación de la concentración de hemoglobina en la policitemia de altura: modelo matemático
Monge, C. (1990) · Bulletin de l'Institut Français d'Études Andines · doi:10.3406/bifea.1990.1017 · Cited by 5
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6 of the 14 references couldn’t be matched to a known paper.
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Beall, C. M., Cavalleri, G. L., Deng, L., Elston, R. C., Gao, Y., Knight, J., Li, C., Li, J. C., Liang, Y., McCormack, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002443107 · Cited by 845
“Chronic mountain sickness remains at that low level throughout adulthood among Tibetans but, in Peruvians, prevalence increases with age from approximately 13% in 20 to 39 y olds to approximately 36% in 55 to 69 y olds at 4,300 m (47).”
BackgroundRegulation of erythropoiesis by hypoxia-inducible factors
Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787
“CMS is usually alleviated by descent to low altitude or by phlebotomy.(162,163) While the disease is prevalent in the Andean population, it is less common in native Tibetans, who live at comparable altitude.”
BackgroundPenaloza, D., & Arias-Stella, J. (2007) · Circulation · doi:10.1161/circulationaha.106.624544 · Cited by 643
Consensus Statement on Chronic and Subacute High Altitude Diseases
Lèon‐Velarde, F., Maggiorini, M., Reeves, J. Τ., Aldashev, A. A., Asmus, I., Bernardi, L., Ge, R.-L., Hackett, P. H., Kobayashi, T., MOORE, L. G., et al. (2005) · High Altitude Medicine & Biology · doi:10.1089/ham.2005.6.147 · Cited by 629
“…1994; León-Velarde et al., 1993; León-Velarde et al., 1994; León-Velarde et al., 1997; León-Velarde et al., 2001; León-Velarde et al., 2003; Monge-C et al., 1992; Monge-C et al., 2001; Monge-M et al., 1928; Moore et al., 1998; Pei et al., 1989; Penaloza, 2003; Penaloza and Sime, 1971;…”
Self-citationHuman Genetic Adaptation to High Altitude
MOORE, L. G. (2001) · High Altitude Medicine & Biology · doi:10.1089/152702901750265341 · Cited by 335
“…et al., 2000) (Sun et al., 1990b) (Mayhew et al., 1990) (Sun et al., 1996) (Mayhew 1991) (Torroni et al., 1994) (Mayhew 1998) (Wiley 1994b) (Monge-C et al., 1992) (Wiley 1994a) (Moraga et al., 2000) (Wu et al., 1998a) (Mortola et al., 1990) (Wu et al., 1998b) (Normand et al., 1992) (Wu et…”
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Metadata
- Authors
- Monge-C, C., Arregui, A., & León-Velarde, F.
- Affiliations
- Universidad Peruana Cayetano Heredia (PE)
- Venue
- International Journal of Sports Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 1992-10
- Volume
- 13
- Issue
- S 1
- Pages
- S79-S81
- ISSN
- 0172-4622 (ISSN-L)
- 1439-3964
- OpenAlex
- W1995517473
- Cited by
- 153
- References
- 14
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 12 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 4
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- International Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Universidad Peruana Cayetano Heredia Institutional Repository (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Physiology (medical) › High Altitude and Hypoxia
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- chronic mountain sickness, high altitude, hypoxemia, polycythemia, erythrocytosis, erythropoietin, hemoglobin levels, respiratory rate, aging, prevalence, headache
- MeSH terms
- Adult, Aged, Aging, Altitude Sickness, Hypoxia, Chronic Disease, Erythropoietin, Homeostasis, Humans, Hypoventilation, Male, Middle Aged, Models, Theoretical, Peru, Polycythemia, Prevalence
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