Cited by 208Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

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The NMDA Antagonist Model for Schizophrenia: Promise and Pitfalls

Abi-Saab, W., D'Souza, D., Moghaddam, B., Krystal, J.·1998·Pharmacopsychiatry

DOI 10.1055/s-2007-979354

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Abstract

Drug models have been extensively used to study the pathophysiology of schizophrenia. While they provide good insight into the neurobiology of this disorder, they have several shortcomings, which if known, help in the interpretation of results. In this paper we will discuss these shortcomings in general, and in relation to the N-methyl D-aspartate antagonist model for schizophrenia. This model has recently received a great deal of attention since both phencyclidine and the structurally related drug ketamine, produce symptoms that extend beyond psychosis per se to include other symptoms associated with schizophrenia. In fact, subanesthetic doses of ketamine in healthy individuals produce not only paranoia and perceptual alterations but also thought disorder, negative symptoms, cognitive deficits, as well as impairment on a number of electrophysiologic tests known to be abnormal in schizophrenia. These effects of ketamine will be discussed with a particular emphasis on implications for the pathophysiology and therapeutics of this disorder.

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Authors: Abi-Saab, W., D'Souza, D., Moghaddam, B., & Krystal, J.
Affiliations: Yale University (US)
ORCID: Moghaddam, B.
Krystal, J.
Venue: Pharmacopsychiatry
Publisher: Georg Thieme Verlag KG
Published: 1998-07
Volume: 31
Issue: S 2
Pages: 104-109
ISSN: 0176-3679 (ISSN-L)
1439-0795
DOI: 10.1055/s-2007-979354
OpenAlex: W2066794669
Cited by: 208
References: 0
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 7 · 2014: 10 · 2013: 7 · 2012: 7
FWCI: 3.74
Type: journal article
Language: en
Open access: closed
Locations: Pharmacopsychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
National Alliance for Research on Schizophrenia and Depression
National Institutes of Health
National Institute of Mental Health (MH 44866, P50MH044866)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: schizophrenia, ketamine, phencyclidine, drug-induced psychosis, thought disorder, negative symptoms, cognitive impairment, schizophrenia pathophysiology
MeSH terms: Anesthetics, Dissociative, Humans, Ketamine, Schizophrenia, Receptors, N-Methyl-D-Aspartate, Excitatory Amino Acid Antagonists

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The NMDA Antagonist Model for Schizophrenia: Promise and Pitfalls

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