The DOI matches its Crossref record.
Myofibrillar Damage Following Intense Eccentric Exercise in Man
Abstract
Muscle soreness that has a delayed onset is a common feature among both athletes and untrained individuals who engage in unusual exercises. This study was designed to provide additional morphological data to assess the relevance and significance of our previous findings that the sore muscles contain fibers with disorganized myofibrillar material. Muscle biopsies were obtained from 12 males (mean age 25 +/- 7 years), who suffered from severe soreness in their thigh muscles 18--72 h following eccentric bicycle exercise. Their strength performance were tested in parallel. Knee extensor strength was decreased at all angular velocities soon after exercise but gradually increased over the subsequent days although slower at the fastest contractions. Disturbances of the cross-striated band pattern were constantly observed. They originated from the myofibrillar Z-band, which showed marked streaming, broadening and, at places, total disruption. The disturbances were found in every second to every third fiber up to 3 days after exercise and in one tenth of the fibers 6 days following the exercise. Type 2 fibers were predominantly affected. Thus, the eccentric exercise gives rise to muscles soreness and influences, on mechanical basis and selectively with regard to fiber type, the fine structure of the contractile apparatus.
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“As the normal progression of damage and regeneration processes occur, disruptions to sarcomeric (contractile apparatus) and sarcolemmal (membrane) structures have been observed within days of the eccentric exercise bout (35, 55, 56).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [56]
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Exercise-Induced Muscle Damage in Humans
Clarkson, P. M., & Hubal, M. J. (2002) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/00002060-200211001-00007 · Cited by 1,478
“concurred with those of Fridén et al.(4) in that biopsy sam-”
BackgroundResultInfluentialDelayed Onset Muscle Soreness: Treatment Strategies and Performance Factors
Cheung, K., Hume, P. A., & Maxwell, L. (2003) · Sports Medicine · doi:10.2165/00007256-200333020-00005 · Cited by 1,350
Muscle damage and inflammation during recovery from exercise.
Peake, J., Neubauer, O., Gatta, P. D. D., & Nosaka, K. (2016) · Journal of applied physiology · doi:10.1152/japplphysiol.00971.2016 · Cited by 740
“Disruption of Z disks and sarcomeres appears to peak between 1 and 3 days after exercise (21, 30, 72, 117), but may remain elevated up to 6 8 days after exercise (30, 43, 117).”
BackgroundCreatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery
Baird, M., Graham, S. M., Baker, J. S., & Bickerstaff, G. F. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/960363 · Cited by 765
“This may be due to a greater recruitment of type II muscle fibres in highintensity eccentric exercise, which have been found to be more susceptible to disruption compared to type I [23, 32].”
BackgroundNew insights into the behavior of muscle during active lengthening
Morgan, D. L. (1990) · Biophysical Journal · doi:10.1016/s0006-3495(90)82524-8 · Cited by 727
Metadata
- Authors
- Fridén, J., Sjöström, M., & Ekblom, B.
- Affiliations
- Karolinska Institutet (SE)
- ORCID
- Venue
- International Journal of Sports Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 1983-08
- Volume
- 04
- Issue
- 03
- Pages
- 170-176
- ISSN
- 0172-4622 (ISSN-L)
- 1439-3964
- OpenAlex
- W2006955286
- Cited by
- 1,005
- References
- 0
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 21 · 2023: 16 · 2022: 22 · 2021: 24 · 2020: 31 · 2019: 27 · 2018: 33 · 2017: 26 · 2016: 28 · 2015: 29 · 2014: 33 · 2013: 37 · 2012: 35
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Muscular Dystrophy Association
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- delayed onset muscle soreness, eccentric exercise, myofibrillar damage, muscle fiber ultrastructure, fast-twitch muscle, quadriceps strength, muscle strength recovery, exercise-induced muscle damage, thigh muscle
- MeSH terms
- Adolescent, Adult, Biopsy, Physical Exertion, Humans, Knee, Male, Microscopy, Electron, Mitochondria, Muscle, Muscle Contraction, Myofibrils, Pain, Time Factors
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