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Polyvinyl Pyrrolidone as a Plasma Expander: Studies on Its Excretion, Distribution and Metabolism
Abstract
POLYVINYL pyrrolidone (P. V. P., Periston or Kollidon), was proposed in 1940 as an effective nontoxic plasma substitute.¶ It is a synthetic, water-soluble, macromolecular polymer, dissolved in buffered physiologic saline solution in a concentration of 3.5 per cent, so as to be nearly isotonic and iso-oncotic with normal plasma (osmotic pressure equivalent to 400 to 450 mm. of water). It was administered to large numbers of soldiers and civilians during the ensuing war years in Germany and since then in other European countries and in the United States. All early reports agreed that it was effective in the treatment of . . .
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Metadata
- Authors
- Ravin, H. A., Seligman, A. M., & Fine, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1952-12-11
- Volume
- 247
- Issue
- 24
- Pages
- 921-929
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1984829006
- Cited by
- 196
- References
- 0
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ravin, H. A., Seligman, A. M., & Fine, J. (1952). Polyvinyl Pyrrolidone as a Plasma Expander: Studies on Its Excretion, Distribution and Metabolism. New England Journal of Medicine. https://doi.org/10.1056/nejm195212112472403
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
