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Zinc Metabolism in Hepatic Dysfunction: Serum Zinc Concentrations in Laënnec's Cirrhosis and Their Validation by Sequential Analysis
Abstract
THE presence of zinc in living organisms and its essentiality as a nutrient for plants and animals have been recognized for many, ears.1 , 2 Normal persons take in about 10 to 15 mg. of zinc a day, most of it being excreted in the feces, which contain about 10 mg. a day; about 300 or 400 microgm. a day is excreted in the urine.3 Most human organs contain zinc, the amounts in different organs varying between 10 and 200 microgm. per gram of wet tissue.4 The serum zinc concentration has been reported to be decreased in several diseases, notably pernicious anemia. . . .
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Citations
Cited by
Zinc requirements and the risks and benefits of zinc supplementation
Maret, W., & Sandstead, H. H. (2006) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2006.01.006 · Cited by 1,119
Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease
Prasad, A. S. (2013) · Advances in Nutrition · doi:10.3945/an.112.003210 · Cited by 919
Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism, and geophagia
Prasad, A. S., Halsted, J. A., & Nadimi, M. (1961) · The American Journal of Medicine · doi:10.1016/0002-9343(61)90137-1 · Cited by 791
Biochemistry, Physiology and Pathology of Zinc
Vallee, B. L. (1959) · Physiological Reviews · doi:10.1152/physrev.1959.39.3.443 · Cited by 420
Self-citationMiyoshi, Y., Tanabe, S., & Suzuki, T. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00405.2015 · Cited by 115
Metadata
- Authors
- Vallee, B. L., Wacker, W. E. C., Bartholomay, A. F., & Robin, E. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1956-08-30
- Volume
- 255
- Issue
- 9
- Pages
- 403-408
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1982153642
- Cited by
- 264
- References
- 0
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Zinc Metabolism in Hepatic Dysfunction: Serum Zinc Concentrations in Laënnec's Cirrhosis and Their Validation by Sequential Analysis. https://app.cochat.ai/papers/10.1056/nejm195608302550901
- The paper
- Vallee, B. L., Wacker, W. E. C., Bartholomay, A. F., & Robin, E. D. (1956). Zinc Metabolism in Hepatic Dysfunction: Serum Zinc Concentrations in Laënnec's Cirrhosis and Their Validation by Sequential Analysis. New England Journal of Medicine. https://doi.org/10.1056/nejm195608302550901
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.