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Chloramphenicol in the Newborn Infant: A Physiologic Explanation of Its Toxicity When Given in Excessive Doses
Abstract
DURING the past few years there has been much concern regarding the increased incidence of nursery infections. This has resulted in the widespread use of antibiotics for prophylaxis as well as for therapy. The variable response of hospital strains of micro-organisms led to a gradual increase in the size of doses being administered. Chloramphenicol has proved to be an effective agent in this field, but doses higher than those recommended for older subjects have been used in many cases. Associated with these high doses of chloramphenicol, several pediatric centers found a number of toxic reactions and a higher mortality in . . .
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Cited by
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Central role of mitochondria in drug-induced liver injury
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Metadata
- Authors
- Weiss, C. F., Glazko, A. J., & Weston, J. K.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1960-04-21
- Volume
- 262
- Issue
- 16
- Pages
- 787-794
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2000742403
- Cited by
- 352
- References
- 0
- FWCI
- 28.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Chloramphenicol in the Newborn Infant: A Physiologic Explanation of Its Toxicity When Given in Excessive Doses. https://app.cochat.ai/papers/10.1056/nejm196004212621601
- The paper
- Weiss, C. F., Glazko, A. J., & Weston, J. K. (1960). Chloramphenicol in the Newborn Infant: A Physiologic Explanation of Its Toxicity When Given in Excessive Doses. New England Journal of Medicine. https://doi.org/10.1056/nejm196004212621601
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
