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Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases
Abstract
THE term aplastic anemia may have various meanings in different clinics. Occasionally, it is used for a condition in which there is peripheral pancytopenia but a normally cellular or even hypercellular bone marrow. Such a state may be associated with a good prognosis even without therapy. As described in this report, aplastic anemia is a physiologic and anatomic failure of the bone marrow, with marked decrease or absence of blood-forming elements in the marrow, peripheral pancytopenia and no splenomegaly, hepatomegaly or lymphadenopathy.§ Most children with this disease die from anemia, hemorrhage or infection, despite treatment with antimicrobial drugs, corticosteroids and . . .
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“Supportive care using hematopoietic growth factors or androgens to boost blood cell production provides transient benefit in some patients, delaying but not obviating the need for more definitive treatment [23–26].”
From Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia (2009) · cites this paper as [23]
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Cited by
Effects of graded doses of testosterone on erythropoiesis in healthy young and older men
Coviello, A. D., Kaplan, B., Lakshman, K. M., Chen, T., Singh, A. B., & Bhasin, S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1692 · Cited by 404
Telomere-driven diseases and telomere-targeting therapies
Martínez, P., & Blasco, M. A. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610111 · Cited by 257
“2; Shahidi and Diamond, 1961; Jaime-Pérez et al., 2011).”
BackgroundBar, C., Huber, N., Beier, F., & Blasco, M. A. (2015) · Haematologica · doi:10.3324/haematol.2015.129239 · Cited by 81
Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia
Müller, L. U. W., & Williams, D. A. (2009) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2009.03.010 · Cited by 31
Metadata
- Authors
- Shahidi, N. T., & Diamond, L. K.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1961-05-11
- Volume
- 264
- Issue
- 19
- Pages
- 953-967
- ISSN
- 0028-4793
- 1533-4406
- Cited by
- 177
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases. https://app.cochat.ai/papers/10.1056/nejm196105112641901
- The paper
- Shahidi, N. T., & Diamond, L. K. (1961). Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases. New England Journal of Medicine. https://doi.org/10.1056/nejm196105112641901
