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Thalidomide Embryopathy in Hybrid Rabbits
Abstract
THE purpose of this paper is to report production of specific malformations of the limbs and kidneys in offspring of rabbits given thalidomide by mouth during the second week of pregnancy (Fig. 1). The experiments were undertaken after the omide as a teratogenic agent in 1962, Somers,2 in England, was able to produce defects of the limbs in rabbits, as a consequence of feeding thalidomide during the eighth through the sixteenth day of pregnancy; his findings were soon confirmed by many reports from European countries, particularly Germany and England, indicated that thalidomide taken during early pregnancy had resulted in the . . .
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“Moreover, it has been shown that species such as mice, rats, and bush babies are resistant to thalidomide-induced teratogenicity (Butler, 1977; Heger et al., 1988; Ingalls et al., 1964; Vickers, 1967)”
From Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome (2018) · cites this paper as Ingalls et al., 1964
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The citation lists haven’t been fetched yet
References 3 · Cited by 25
Research works printed but not linked: 4
- Pfeiffer, 1962, München. med. Wchnschr., 104, 68
- 10.1016/S0140-6736(62)91943-8 · DOI · Paper page
- 10.1016/S0140-6736(62)92800-3 · DOI
- 10.1080/00039896.1962.10663250 · DOI
Metadata
- Authors
- Ingalls, T. H., Curley, F. J., & Zappasodi, P.
- Affiliations
- University of Pennsylvania (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1964-08-27
- Volume
- 271
- Issue
- 9
- Pages
- 441-444
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1979974484
- Cited by
- 25
- References
- 3
- Citations by year
- 2021: 1 · 2018: 1 · 2015: 1 · 2013: 1
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Congenital limb and hand anomalies
- Keywords
- thalidomide, thalidomide embryopathy, teratogenicity, limb malformations, kidney malformation, prenatal drug exposure, rabbits, congenital malformations
- MeSH terms
- Abnormalities, Drug-Induced, Abnormalities, Multiple, Extremities, Female, Fetal Diseases, Humans, Kidney Diseases, Pregnancy, Rabbits, Research, Thalidomide, Toxicology, Uterus
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- CoChat. (2026). Citation check: Thalidomide Embryopathy in Hybrid Rabbits. https://app.cochat.ai/papers/10.1056/nejm196408272710904
- The paper
- Ingalls, T. H., Curley, F. J., & Zappasodi, P. (1964). Thalidomide Embryopathy in Hybrid Rabbits. New England Journal of Medicine. https://doi.org/10.1056/nejm196408272710904
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
