The DOI matches its Crossref record.
Carbon Dioxide Titration Curve of Normal Man: Effect of Increasing Degrees of Acute Hypercapnia on Acid-Base Equilibrium
Abstract
ALTHOUGH it has long been recognized that defense of pH during acute hypercapnia is dependent on the generation of bicarbonate by body buffers,1 , 2 the quantitative aspects of the response to graded increases in carbon dioxide tension (pCO2) have not been defined in man. The characterization of such a "whole-body titration curve" § should serve the important function of providing a physiologic background against which complex acid–base disturbances in the patient with acute respiratory acidosis might be evaluated.The present study has employed a large environmental chamber to examine the acid–base response of unanesthetized man to progressive elevation of arterial . . .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Changes in plasma potassium concentration during acute acid-base disturbances
Adrogué, H. J., & Madias, N. E. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90182-0 · Cited by 388
Secondary Responses to Altered Acid-Base Status: The Rules of Engagement
Adrogué, H. J., & Madias, N. E. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009121211 · Cited by 91
Metadata
- Authors
- Brackett, N. C., Cohen, J. J., & Schwartz, W. B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1965-01-07
- Volume
- 272
- Issue
- 1
- Pages
- 6-12
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2324670142
- Cited by
- 326
- References
- 0
- FWCI
- 39.11
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Carbon Dioxide Titration Curve of Normal Man: Effect of Increasing Degrees of Acute Hypercapnia on Acid-Base Equilibrium. https://app.cochat.ai/papers/10.1056/nejm196501072720102
- The paper
- Brackett, N. C., Cohen, J. J., & Schwartz, W. B. (1965). Carbon Dioxide Titration Curve of Normal Man: Effect of Increasing Degrees of Acute Hypercapnia on Acid-Base Equilibrium. New England Journal of Medicine. https://doi.org/10.1056/nejm196501072720102
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
