The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Blood Glucose in the Neonate and Its Clinical Significance
Abstract
LEVELS of total reducing substance, true sugar and glucose have been measured in the blood of newborn infants since 1911. The early reports have been reviewed by Norval et al.1 , 2 Although an extensive literature exists, there is still disagreement over which levels of blood sugar are normal in the neonate and which are hypoglycemic or hyperglycemic. Much of this confusion results from differences in technics in collecting, precipitating and analyzing the sugar, as well as the duration of fasting before sampling. An attempt will be made to explain the differences in reported results, to present current data for normal ranges . . .
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“During the first 24–48 hours of life, as normal neonates transition from intrauterine to extrauterine life, their plasma glucose (PG) concentrations are typically lower than later in life.1–3”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [1]
In the citing paper
“In normal newborns, the mean PG concentration rises to >70 mg/dL (3.9 mmol/L) after 48 hours of age.1”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [1]
In the citing paper
“In normal newborn infants, PG concentration commonly decreases immediately after birth to levels below those in older infants and children.”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [1]
In the citing paper
“As the glucose stimulated-insulin secretion mechanism matures, mean PG concentration in normal newborns increases and by 72 hours of age is similar to those in older infants and children1,2”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [1]
Citations
Cites
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SYMPTOMATIC NEONATAL HYPOGLYCEMIA
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Self-citationHYPOGLYCÆMIA IN THE NEWBORN INFANT
Brown, R., & Wallis, P. G. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91981-0 · Cited by 104
Hereditary Fructose Intolerance
Cornblath, M., Rosenthal, I. M., Reisner, S. H., Wybregt, S. H., & Crane, R. K. (1963) · New England Journal of Medicine · doi:10.1056/nejm196312122692401 · Cited by 86
Self-citationInfantile Hypoglycaemia due to Inherited Deficiency of Glycogen Synthetase in Liver
Lewis, G. M., Spencer‐Peet, J., & Stewart, K. (1963) · Archives of Disease in Childhood · doi:10.1136/adc.38.197.40 · Cited by 76
Congenital Temporary Diabetes Mellitus
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The Significance of Hypoglycaemia in the Newborn Infant of the Diabetic Woman
Farquhar, J. W. (1956) · Archives of Disease in Childhood · doi:10.1136/adc.31.157.203 · Cited by 57
Blood sugar in newborn infants
Norval, M. A., Kennedy, R. L. J., & Berkson, J. (1949) · The Journal of Pediatrics · doi:10.1016/s0022-3476(49)80091-6 · Cited by 53
STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN INFANT
Baens, G. S., Lundeen, E. C., & Cornblath, M. (1963) · PEDIATRICS · doi:10.1542/peds.31.4.580 · Cited by 48
Self-citationBaens, G. S., Lundeen, E. C., Cornblath, M., MORRISON, M., & Harr, C. (1963) · PubMed · Cited by 43
Self-citationControl of the Blood Sugar Level in the Neonatal Period
Farquhar, J. W. (1954) · Archives of Disease in Childhood · doi:10.1136/adc.29.148.519 · Cited by 38
The syndrome of transient diabetes
Gerrard, J. W., & Chin, W. (1962) · The Journal of Pediatrics · doi:10.1016/s0022-3476(62)80234-0 · Cited by 34
Blood sugar values in premature infants
Norval, M. A. (1950) · The Journal of Pediatrics · doi:10.1016/s0022-3476(50)80203-2 · Cited by 34
DIABETES MELLITUS IN INFANTS UNDER ONE YEAR OF AGE
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The incidence of neonatal hypoglycemia in a nursery for premature infants
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Self-citationArey, S. L. (1953) · PEDIATRICS · doi:10.1542/peds.11.2.140 · Cited by 27
Blood Sugar Studies on Premature Babies
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Familial Neonatal Hypoglycemia A Syndrome Resembling Foetopathia Diabetica
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Manual of American Society of Clinical Pathologists Workshop on Glucose
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Research works printed but not linked: 1
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Cited by
Sorted by citations
Thornton, P. S., Stanley, C. A., De Leon, D. D., Harris, D., Haymond, M. W., Hussain, K., Levitsky, L. L., Murad, M. H., Rozance, P. J., Simmons, R. A., et al. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.03.057 · Cited by 625
“9 mmol/L) after 48 hours of age.(1) This is similar to the mean glucose concentration in older children and adults.”
Patterns of Cerebral Injury and Neurodevelopmental Outcomes After Symptomatic Neonatal Hypoglycemia
Burns, C. M., Rutherford, M., Boardman, J. P., & Cowan, F. M. (2008) · PEDIATRICS · doi:10.1542/peds.2007-2822 · Cited by 515
Patterns of metabolic adaptation for preterm and term infants in the first neonatal week.
Hawdon, J. M., Platt, M. W., & Aynsley-Green, A. (1992) · Archives of Disease in Childhood · doi:10.1136/adc.67.4_spec_no.357 · Cited by 336
Plasma glucose values in normal neonates: a new look
Srinivasan, G., Pildes, R. S., Cattamanchi, G., Voora, S., & Lilien, L. D. (1986) · The Journal of Pediatrics · doi:10.1016/s0022-3476(86)80588-1 · Cited by 329
Re-evaluating “transitional neonatal hypoglycemia”: mechanism and implications for management
Stanley, C. A., Rozance, P. J., Thornton, P. S., De Leon, D. D., Harris, D., Haymond, M. W., Hussain, K., Levitsky, L. L., Murad, M. H., Simmons, R. A., et al. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.02.045 · Cited by 245
Metadata
- Authors
- Cornblath, M., & Reisner, S. H.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Bnai Zion Medical Center (IL)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1965-08-12
- Volume
- 273
- Issue
- 7
- Pages
- 378-381
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2024326266
- Cited by
- 190
- References
- 20
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 5 · 2013: 3 · 2012: 11
- FWCI
- 17.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- neonatal blood glucose, hypoglycemia, hyperglycemia, neonates, reducing substances
- MeSH terms
- Blood Glucose, Glucose, Humans, Hyperglycemia, Hypoglycemia, Hypoglycemic Agents, Infant, Newborn, Insulin, Reference Values
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