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Prevention of Wilson's Disease in Asymptomatic Patients
Abstract
A biochemical diagnosis of Wilson's disease was established in 53 asymptomatic subjects, ranging in age from 15 months to 31 years. None had any pathognomonic physical sign of the disease. In 36 of these patients a liver biopsy specimen was examined by light microscopy, and in 31 histologic changes were found. Forty-two of these patients have been treated with a de-copperizing regimen, based on the continued and daily administration of D,L-penicillamine or D-penicillamine, and have remained asymptomatic during a period of observation of 142 patient years. An estimate, based on the natural history of Wilson's disease in 121 symptomatic patients, suggests that during this interval symptoms of the disorder could have been expected to develop in at least eight of these subjects.
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Citations
Cited by
Oral zinc therapy for Wilson's disease
BREWER, G. J., HILL, G. M., PRASAD, A. S., COSSACK, Z. T., & RABBANI, P. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-3-314 · Cited by 244
Appenzeller‐Herzog, C., Mathes, T., Heeres, M. L. S., Weiss, K. H., Houwen, R. H. J., & Ewald, H. (2019) · Liver International · doi:10.1111/liv.14179 · Cited by 51
Metadata
- Authors
- Sternlieb, I., & Scheinberg, I. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1968-02-15
- Volume
- 278
- Issue
- 7
- Pages
- 352-359
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1989815568
- Cited by
- 307
- References
- 0
- FWCI
- 25.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Prevention of Wilson's Disease in Asymptomatic Patients. https://app.cochat.ai/papers/10.1056/nejm196802152780702
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- Sternlieb, I., & Scheinberg, I. H. (1968). Prevention of Wilson's Disease in Asymptomatic Patients. New England Journal of Medicine. https://doi.org/10.1056/nejm196802152780702
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
