The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Immunologic Factors and Clinical Activity in Systemic Lupus Erythematosus
Abstract
To clarify the association between certain immunologic factors and clinical activity in patients with systemic lupus erythematosus, 96 patients were studied. Those with antibodies to deoxyribonucleic acid (DNA) or heat-denatured DNA, or with serum complement levels of less than 50 C′H50 units per ml, were more likely to have renal involvement. Very low complement levels and high titers of complement-fixing antibodies to DNA were always associated with active disease, especially active renal disease, whereas the absence of these abnormalities usually indicated inactive renal disease. A 50 per cent fall in serum complement levels in 22 patients was accompanied by, or preceded the onset of, active nephritis in 19 patients. These serologic factors may thus reflect the in vivo formation of immune complexes that cause nephritis. Serial immunochemical observations may be useful in the management of patients with systemic lupus erythematosus.
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Cites
SYSTEMIC LUPUS ERYTHEMATOSUS: REVIEW OF THE LITERATURE AND CLINICAL ANALYSIS OF 138 CASES
HARVEY, A. M., SHULMAN, L. E., TUMULTY, P. A., CONLEY, C. L., & SCHOENRICH, E. H. (1954) · Medicine · doi:10.1097/00005792-195412000-00001 · Cited by 993
Cited by
Ter Borg, E. J., Horst, G., Hummel, E. J., Limburg, P. C., & Kallenberg, C. G. M. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330505 · Cited by 572
Izui, S., Lambert, P. H., & Miescher, P. A. (1976) · The Journal of experimental medicine · doi:10.1084/jem.144.2.428 · Cited by 313
Prevention of relapses in systemic lupus erythematosus
Bootsma, H., Spronk, P., de Boer, G., Limburg, P., Kallenberg, C., Derksen, R., Wolters-Dicke, J., Gmelig-Meyling, F., Kater, L., & Hermans, J. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90114-0 · Cited by 290
Guidelines for immunologic laboratory testing in the rheumatic diseases: Anti‐DNA antibody tests
Kavanaugh, A. F., Solomon, D. H., & The American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines (2002) · Arthritis Care & Research · doi:10.1002/art.10558 · Cited by 225
Toward new criteria for systemic lupus erythematosus-a standpoint
Aringer, M., Dörner, T., Leuchten, N., & Johnson, S. R. (2016) · Lupus · doi:10.1177/0961203316644338 · Cited by 93
Ramos-Casals, M., Campoamor, M. T., Chamorro, A., Salvador, G., Segura, S., Botero, J. C., Yagüe, J., Cervera, R., Ingelmo, M., & Font, J. (2004) · Lupus · doi:10.1191/0961203304lu1080oa · Cited by 91
KONSTANTINOV, K. N., & RUSSANOVA, V. R. (1987) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1987.tb04924.x · Cited by 4
Metadata
- Authors
- Schur, P. H., & Sandson, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1968-03-07
- Volume
- 278
- Issue
- 10
- Pages
- 533-538
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2316085552
- Cited by
- 587
- References
- 1
- FWCI
- 29.83
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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