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Urinary Xanthine Stones-a Rare Complication of Allopurinol Therapy
Abstract
SINCE its clinical introduction in 1964, allopurinol (4-hydroxypyrazolo-[3,4-d]-pyrimidine) has been increasingly used for the treatment of hyperuricemia of gout,1 , 2 many neoplastic diseases and other metabolic disorders. Allopurinol and its principal metabolic product, oxipurinol (alloxanthine, oxoallopurinol), inhibit the enzyme, xanthine oxidase, that normally converts hypoxanthine to xanthine, and xanthine to uric acid. The concentration of these oxypurine precursors of uric acid in blood and urine thus increases in patients treated with allopurinol.Although the formation of urinary xanthine stones has been anticipated as a possible complication of allopurinol therapy, to date this occurrence has not been documented in the clinical use . . .
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Citations
Cited by
Howard, S. C., Jones, D. P., & Pui, C.-H. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0904569 · Cited by 1,044
Pui, C.-H., Mahmoud, H. H., Wiley, J. M., Woods, G. M., Leverger, G., Camitta, B., Hastings, C., Blaney, S. M., Relling, M. V., & Reaman, G. H. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.3.697 · Cited by 361
Hyperuricemia and Gout: Classification, Complications and Management
Boss, G. R., & Seegmiller, J. E. (1979) · New England Journal of Medicine · doi:10.1056/nejm197906283002604 · Cited by 281
Self-citationDrug-induced kidney stones and crystalline nephropathy: pathophysiology, prevention and treatment
Daudon, M., Frochot, V., Bazin, D., & Jungers, P. (2018) · Drugs · doi:10.1007/s40265-017-0853-7 · Cited by 191
Metadata
- Authors
- Greene, M. L., Fujimoto, W. Y., & Seegmiller, J. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1969-02-20
- Volume
- 280
- Issue
- 8
- Pages
- 426-427
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2336623503
- Cited by
- 165
- References
- 0
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greene, M. L., Fujimoto, W. Y., & Seegmiller, J. E. (1969). Urinary Xanthine Stones-a Rare Complication of Allopurinol Therapy. New England Journal of Medicine. https://doi.org/10.1056/nejm196902202800806
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