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Functional Asplenia in Sickle-Cell Anemia
Abstract
Observation of Howell—Jolly bodies in the blood of children with sickle-cell anemia suggested the paradox of splenic hypofunction despite clinical splenomegaly. Spleen scans were performed with a sulfur colloid tagged with radioactive technetium (99mTc). No splenic uptake of the colloid was seen in 11 of 12 children with sickle-cell anemia, although many had enlarged spleens. Twenty-five controls, including children with sickle-cell trait and Hgb SC and Hgb S-β thalassemia diseases, regularly demonstrated splenic uptake. Functional asplenia in children with sickle-cell anemia may be a pertinent factor in the susceptibility to infections — particularly pneumococcal infections — that is characteristic of this disease.
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Citations
Cited by
The spleen and sickle cell disease: the sick(led) spleen
Brousse, V., Buffet, P., & Rees, D. (2014) · British Journal of Haematology · doi:10.1111/bjh.12950 · Cited by 294
Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism.
Kenny, M. W., George, A. J., & Stuart, J. (1980) · Journal of Clinical Pathology · doi:10.1136/jcp.33.7.622 · Cited by 79
Opsonins: Their function, identity, and clinical significance
Winkelstein, J. A. (1973) · The Journal of Pediatrics · doi:10.1016/s0022-3476(73)80062-9 · Cited by 69
Metadata
- Authors
- Pearson, H. A., Spencer, R. P., & Cornelius, E. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1969-10-23
- Volume
- 281
- Issue
- 17
- Pages
- 923-926
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2067977670
- Cited by
- 425
- References
- 0
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pearson, H. A., Spencer, R. P., & Cornelius, E. A. (1969). Functional Asplenia in Sickle-Cell Anemia. New England Journal of Medicine. https://doi.org/10.1056/nejm196910232811703
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