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Hemoglobin Components in Patients with Diabetes Mellitus
Abstract
An increase in a minor hemoglobin component closely resembling hemoglobin AIc in which one or more hexoses are bound to the beta-polypeptide chains was observed in a previous study of diabetic patients. In the present study the proportions of chromatographically rapid (fast) minor components of hemoglobin, 75 to 80 per cent of which is accounted for by hemoglobin AIc, were quantified by a modified Chromatographic method in 20 normal and 100 diabetic subjects. Mean values for the proportions of fast hemoglobin components (glycohemoglobin) in diabetes showed a nearly twofold increase over values found in normal subjects. The increased proportions of these fast components did not appear to be related to the age of the patients, or to the duration, therapy or complications of diabetes. The increase in proportions of glycohemoglobin in diabetes mellitus appears to be another example of increased glycoproteins in this disorder.
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Citations
Cited by
Riess, J. G. (2001) · Chemical Reviews · doi:10.1021/cr970143c · Cited by 773
Correlations between Antepartum Maternal Metabolism and Intelligence of Offspring
Rizzo, T., Metzger, B. E., Burns, W. J., & Burns, K. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251303 · Cited by 707
Goldstein, D. E., Little, R. R., Lorenz, R. A., Malone, J. I., Nathan, D., Peterson, C. M., & Sacks, D. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1761 · Cited by 625
Does accumulation of advanced glycation end products contribute to the aging phenotype?
Semba, R. D., Nicklett, E. J., & Ferrucci, L. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq074 · Cited by 490
Cahill, G. F., Etzwiler, D. D., & Freinkel, N. (1976) · New England Journal of Medicine · doi:10.1056/nejm197604292941811 · Cited by 301
Metadata
- Authors
- Trivelli, L. A., Ranney, H. M., & Lai, H.-T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1971-02-18
- Volume
- 284
- Issue
- 7
- Pages
- 353-357
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1985792504
- Cited by
- 839
- References
- 0
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Trivelli, L. A., Ranney, H. M., & Lai, H.-T. (1971). Hemoglobin Components in Patients with Diabetes Mellitus. New England Journal of Medicine. https://doi.org/10.1056/nejm197102182840703
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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