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Tartrate-Resistant Acid Phosphatase Isoenzyme in the Reticulum Cells of Leukemic Reticuloendotheliosis
Abstract
Acid phosphatase activity in the reticulum cells of leukemic reticuloendotheliosis is quantitatively and qualitatively different from that in the lymphosarcoma cells of lymphosarcoma and in lymphocytes of chronic lymphocytic leukemia. Enzyme activity in the reticulum cells is strong and tartrate resistant, whereas that in the lymphoid cells of the other two diseases is very weak and is inhibited by tartrate. A combined cytochemical and electrophoretic study indicates that this tartrate-resistant enzyme activity represents isoenzyme 5. It is present almost exclusively in the reticulum cells and not in other hemic cells in leukemic reticuloendotheliosis. It is not present in the lymphoid cells in lymphosarcoma or chronic lymphocytic leukemia. It may be used as the marker enzyme to diagnose leukemic reticuloendotheliosis and to trace the origin of the "reticulum cells" ("hairy cells") in the reticuloendothelial system.
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Citations
Cited by
CLASSIFICATION OF NON-HODGKIN'S LYMPHOMAS
Bennett, M., Farrer-Brown, G., Henry, K., Jelliffe, A. M., Gerard-Marchant, R., Hamlin, I., Lennert, K., Rilke, F., Stansfeld, A. G., & Van Unnik, J. A. M. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91786-3 · Cited by 555
Clinical significance of the human acid phosphatases
Yam, L. T. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90630-5 · Cited by 292
Self-citationA Second Isolate of HTLV-II Associated with Atypical Hairy-Cell Leukemia
Rosenblatt, J. D., Golde, D. W., Wachsman, W., Giorgi, J. V., Jacobs, A., Schmidt, G. M., Quan, S., Gasson, J. C., & Chen, I. S. Y. (1986) · New England Journal of Medicine · doi:10.1056/nejm198608073150606 · Cited by 278
Underexpression of RhoH in Hairy Cell Leukemia
Galiègue-Zouitina, S., Delestré, L., Dupont, C., Troussard, X., & Shelley, C. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5661 · Cited by 34
Metadata
- Authors
- Yam, L. T., Li, C. Y., & Lam, K. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1971-02-18
- Volume
- 284
- Issue
- 7
- Pages
- 357-360
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341438847
- Cited by
- 415
- References
- 0
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yam, L. T., Li, C. Y., & Lam, K. W. (1971). Tartrate-Resistant Acid Phosphatase Isoenzyme in the Reticulum Cells of Leukemic Reticuloendotheliosis. New England Journal of Medicine. https://doi.org/10.1056/nejm197102182840704
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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