The DOI matches its Crossref record.
Pathogenesis of Escherichia coli Diarrhea
Abstract
Two Escherichia coli strains isolated in Vietnam from American soldiers with diarrhea and acute "colitis" were examined for virulence in both in vitro and in vivo experimental models. Their biologic properties were compared with those of an enterotoxin-producing Esch. coli strain implicated in disease of swine as well as with those of four other Esch. coli and a virulent shigella strain. The two Vietnam strains produced an enterotoxin in a rabbit ileal-loop model and in volunteers caused a diarrheal syndrome resembling that of cholera. Two nontoxigenic Esch. coli strains gave evidence of penetrating epithelial cells in laboratory models and caused a shigella-like illness in man characterized by dysentery, tenesmus, urgency, hyperpyrexia and hypotension with systemic toxemia. Thus, strains of Esch. coli can cause disease in man by at least two mechanisms: elaboration of a cholera-like enterotoxin; and shigella-like intestinal epithelial penetration.
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Citations
Cited by
Evans, D. G., Evans, D. J., & Tjoa, W. (1977) · Infection and Immunity · doi:10.1128/iai.18.2.330-337.1977 · Cited by 527
Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion
Sears, C. L., & Kaper, J. B. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.1.167-215.1996 · Cited by 508
Bavishi, C., & DuPont, H. L. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04874.x · Cited by 480
Self-citationBoudeau, J., Glasser, A.-L., Masseret, E., Joly, B., & Darfeuille-Michaud, A. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4499-4509.1999 · Cited by 448
ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults
Riddle, M. S., DuPont, H. L., & Connor, B. A. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.126 · Cited by 435
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Metadata
- Authors
- DuPont, H. L., Formal, S. B., Hornick, R. B., Snyder, M. J., Libonati, J. P., Sheahan, D. G., LaBrec, E. H., & Kalas, J. P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1971-07
- Volume
- 285
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335715324
- Cited by
- 667
- References
- 0
- FWCI
- 33.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pathogenesis of Escherichia coli Diarrhea. https://app.cochat.ai/papers/10.1056/nejm197107012850101
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- DuPont, H. L., Formal, S. B., Hornick, R. B., Snyder, M. J., Libonati, J. P., Sheahan, D. G., LaBrec, E. H., & Kalas, J. P. (1971). Pathogenesis of Escherichia coli Diarrhea. New England Journal of Medicine. https://doi.org/10.1056/nejm197107012850101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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