The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Defective Cardiac Parasympathetic Control in Patients with Heart Disease
Abstract
To define the state of the parasympathetic nervous system in heart failure, parasympathetic blockade with atropine was induced after adrenergic blockade with propranolol in 12 normal subjects and in nine patients with heart disease. Atropine elevated heart rate by 55 ± 9 per cent in normal subjects, but by only 23 ± 8 per cent in patients with heart disease (p less than 0.05). In 23 control subjects and 22 patients, transient elevations in arterial pressure were produced by intravenous injections of phenylephrine, and successive R-R intervals were plotted as a function of systolic pressure. The slowing of heart rate per unit rise in systolic arterial pressure averaged 16.0 ±1.8 msec per millimeter of mercury in normal subjects but only 3.70 ± 0.8 msec per millimeter of mercury in the patients (p less than 0.001). Baroreceptor-induced slowing of heart rate in normal subjects was shown to be mediated by the parasympathetic nervous system since it could be abolished with atropine. These findings point to a profound abnormality in parasympathetic cardiovascular regulation in heart disease.
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Citations
Cites
The normal range and determinants of the intrinsic heart rate in man
Jose, A. D., & Collison, D. (1970) · Cardiovascular Research · doi:10.1093/cvr/4.2.160 · Cited by 585
Cited by
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120
Imai, K., Sato, H., Hori, M., Kusuoka, H., Ozaki, H., Yokoyama, H., Takeda, H., Inoue, M., & Kamada, T. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90150-3 · Cited by 991
Baroreflex Sensitivity: Measurement and Clinical Implications
La Rovere, M. T., Pinna, G. D., & Raczak, G. (2008) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2008.00219.x · Cited by 659
FRANCIS, G. S., SIEGEL, R. M., GOLDSMITH, S. R., OLIVARI, M. T., LEVINE, T. B., & COHN, J. N. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-1-1 · Cited by 579
Risk stratification for sudden cardiac death: Current status and challenges for the future
Wellens, H. J. J., Schwartz, P. J., Lindemans, F. W., Buxton, A. E., Goldberger, J. J., Hohnloser, S. H., Huikuri, H. V., Kaab, S., La Rovere, M. T., Malik, M., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu176 · Cited by 405
Metadata
- Authors
- Eckberg, D. L., Drabinsky, M., & Braunwald, E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1971-10-14
- Volume
- 285
- Issue
- 16
- Pages
- 877-883
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1976824259
- Cited by
- 953
- References
- 1
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eckberg, D. L., Drabinsky, M., & Braunwald, E. (1971). Defective Cardiac Parasympathetic Control in Patients with Heart Disease. New England Journal of Medicine. https://doi.org/10.1056/nejm197110142851602
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
