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Synthetic Thyrotropin-Releasing Hormone: A Potent Stimulator of Thyrotropin Secretion in Man
Abstract
Abstract Synthetic thyrotropin-releasing hormone (TRH) was administered by single intravenous injection to 79 healthy male volunteers and seven patients with secondary hypothyroidism. Plasma thyrotropin (TSH), growth hormone (GH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and cortisol concentrations were measured before and after TRH administration. In the normal subjects, the mean base-line TSH concentration was 4.5 μU per milliliter. Plasma TSH rose promptly to a peak of 14.0 μU per milliliter 30 minutes after TRH injection. No rises were observed in the other plasma hormones measured. In the patients with secondary hypothyroidism, TRH failed to elevate TSH. No evidence of toxicity and no serious side effects were seen after TRH administration. TRH is a potent and nontoxic stimulator of TSH release in man and is a useful diagnostic compound in testing pituitary TSH reserve. The availability of TRH now makes possible the recognition of hypothalamic hypothyroidism.
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Citations
Cited by
Kastin, A., Ehrensing, R., Schalch, D., & Anderson, M. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92028-4 · Cited by 369
Self-citationThyrotropin-releasing hormone stimulation test in patients with pituitary pathology
Hartoft-Nielsen, M.-L., Lange, M., Rasmussen, Å. K., Scherer, S., Zimmermann-Belsing, T., & Feldt-Rasmussen, U. (2004) · Hormone Research in Paediatrics · doi:10.1159/000075239 · Cited by 47
NEW INSIGHTS INTO THE HYPOTHALAMIC-PITUITARY-THYROID AXIS
Duntas, L. (2016) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2016.125 · Cited by 7
Metadata
- Authors
- Anderson, M. S., Bowers, C. Y., Kastin, A. J., Schalch, D. S., Schally, A. V., Snyder, P. J., Utiger, R. D., Wilber, J. F., & Wise, A. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1971-12-02
- Volume
- 285
- Issue
- 23
- Pages
- 1279-1283
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320571074
- Cited by
- 170
- References
- 0
- FWCI
- 27.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Synthetic Thyrotropin-Releasing Hormone: A Potent Stimulator of Thyrotropin Secretion in Man. https://app.cochat.ai/papers/10.1056/nejm197112022852302
- The paper
- Anderson, M. S., Bowers, C. Y., Kastin, A. J., Schalch, D. S., Schally, A. V., Snyder, P. J., Utiger, R. D., Wilber, J. F., & Wise, A. J. (1971). Synthetic Thyrotropin-Releasing Hormone: A Potent Stimulator of Thyrotropin Secretion in Man. New England Journal of Medicine. https://doi.org/10.1056/nejm197112022852302
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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