The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Life Expectancy and Causes of Death in the Marfan Syndrome
Abstract
Abstract The Marfan syndrome is a dominantly inherited disorder of connective tissue with multisystem involvement. The cardiac complications, particularly aortic dilatation, dissection and rupture and involvement of the aortic and mitral valves, lead to a greatly reduced life expectancy. This poor survival was demonstrated in a series of 257 patients with the Marfan syndrome. The average age at death for the 72 deceased patients was 32 years. Cardiac problems led to 52 of the 56 deaths of known cause, with aortic dilatation and its complications accounting for 80 per cent of these. Congestive heart failure, myocardial infarction and bacterial endocarditis were other cardiac causes of death. In patients with early aortic changes treatment with propranolol or reserpine is suggested. These agents decrease myocardial contractility and diminish the pulsatile flow stress on the weakened aorta.
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Citations
Cites
Maximum utilization of the life table method in analyzing survival
Cutler, S. J., & Ederer, F. (1958) · Journal of Chronic Diseases · doi:10.1016/0021-9681(58)90126-7 · Cited by 2,870
Cited by
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Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
Michelena, H. I., Prakash, S. K., Della Corte, A., Bissell, M. M., Anavekar, N., Mathieu, P., Bossé, Y., Limongelli, G., Bossone, E., Benson, D. W., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.007851 · Cited by 442
Does This Patient Have an Acute Thoracic Aortic Dissection?
Klompas, M. (2002) · JAMA · doi:10.1001/jama.287.17.2262 · Cited by 369
Malaisrie, S. C., Szeto, W. Y., Halas, M., Girardi, L. N., Coselli, J. S., Sundt, T. M., Chen, E. P., Fischbein, M. P., Gleason, T. G., Okita, Y., et al. (2021) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2021.04.053 · Cited by 348
Marfan Syndrome: Long-term Survival and Complications After Aortic Aneurysm Repair
Finkbohner, R., Johnston, D., Crawford, E. S., Coselli, J., & Milewicz, D. M. (1995) · Circulation · doi:10.1161/01.cir.91.3.728 · Cited by 309
Metadata
- Authors
- Murdoch, J. L., Walker, B. A., Halpern, B. L., Kuzma, J. W., & McKusick, V. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1972-04-13
- Volume
- 286
- Issue
- 15
- Pages
- 804-808
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2325125905
- Cited by
- 763
- References
- 1
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Life Expectancy and Causes of Death in the Marfan Syndrome. https://app.cochat.ai/papers/10.1056/nejm197204132861502
- The paper
- Murdoch, J. L., Walker, B. A., Halpern, B. L., Kuzma, J. W., & McKusick, V. A. (1972). Life Expectancy and Causes of Death in the Marfan Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejm197204132861502
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
