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C-Cell Hyperplasia Preceding Medullary Thyroid Carcinoma
Abstract
Two sisters at risk for hereditary medullary carcinoma and having small but progressive increases of serum calcitonin in response to calcium infusion underwent thyroidectomy. The thyroid glands were studied for C-cell distribution. Middle and upper portions of the lateral thyroid lobes showed marked increases and clustering of calcitonin-containing cells in comparison with normal thyroid glands. Elevated calcitonin content (670 to 4100 Medical Research Council mU per gram), as compared to similar regions in normal thyroid tissue (<0.6 to 50.0 Medical Research Council mU per gram), correlated precisely with the cytologic localization. Histologic characteristics of the cells had the appearance of a preinvasive hyperplastic process. A third case from another kindred was studied with similar findings. C-cells thus appear to be distributed inhomogeneously in normal human thyroid tissue; an early change in persons destined to development of hereditary tumors of these cells is a multicentric, but anatomically restricted, increase in numbers of cells. (N Engl J Med 289:437–441, 1973)
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Cited by
Medullary Thyroid Cancer: Management Guidelines of the American Thyroid Association
Kloos (Chair), R. T., Eng, C., Evans, D. B., Francis, G. L., Gagel, R. F., Gharib, H., Moley, J. F., Pacini, F., Ringel, M. D., Schlumberger, M., et al. (2009) · Thyroid · doi:10.1089/thy.2008.0403 · Cited by 1,357
Bjerre Knudsen, L., Madsen, L. W., Andersen, S., Almholt, K., de Boer, A. S., Drucker, D. J., Gotfredsen, C., Egerod, F. L., Hegelund, A. C., Jacobsen, H., et al. (2010) · Endocrinology · doi:10.1210/en.2009-1272 · Cited by 672
Becker, K. L., Nylén, E. S., White, J. C., Müller, B., & Snider, R. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021444 · Cited by 578
Lips, C., Landsvater, R. M., Hoppener, J., Geerdink, R. A., Blijham, G., van Veen, J. M. J.-S., van Gils, A., de Wit, M. J., Zewald, R. A., Berends, M., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199409293311302 · Cited by 454
Prophylactic Thyroidectomy in Multiple Endocrine Neoplasia Type 2A
Skinner, M. A., Moley, J. A., Dilley, W. G., Owzar, K., DeBenedetti, M. K., & Wells, S. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043999 · Cited by 381
Metadata
- Authors
- Wolfe, H. J., Melvin, K. E. W., Cervi-Skinner, S. J., AL Saadi, A. A., Juliar, J. F., Jackson, C. E., & Tashjian, A. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1973-08-30
- Volume
- 289
- Issue
- 9
- Pages
- 437-441
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2323916369
- Cited by
- 449
- References
- 0
- FWCI
- 21.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wolfe, H. J., Melvin, K. E. W., Cervi-Skinner, S. J., AL Saadi, A. A., Juliar, J. F., Jackson, C. E., & Tashjian, A. H. (1973). C-Cell Hyperplasia Preceding Medullary Thyroid Carcinoma. New England Journal of Medicine. https://doi.org/10.1056/nejm197308302890901
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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