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Hyperglycemia-Induced Hyponatremia — Calculation of Expected Serum Sodium Depression
Abstract
FOR at least 1/4 century clinicians have recognized that hyperglycemia depresses serum sodium concentration.1 Since glucose is largely restricted to extracellular fluid, an increase in its concentration moves water out of cells, causing dilution of extracellular solute. It is useful to assess the expected sodium decrease for a given glucose level, because deviations from such a predicted value establish the diagnosis of hyponatremia or hypernatremia that may require therapy in addition to correction of the hyperglycemia. Most clinicians use the rule of thumb that there is a 2.8 mEq per liter decrease in serum sodium for every 100 mg per . . .
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Citations
Cited by
Management of Hyperglycemic Crises in Patients With Diabetes
Kitabchi, A. E., Umpierrez, G. E., Murphy, M. B., Barrett, E. J., Kreisberg, R. A., Malone, J. I., & Wall, B. M. (2001) · Diabetes Care · doi:10.2337/diacare.24.1.131 · Cited by 710
Wolfsdorf, J. I., Glaser, N., Agus, M., Fritsch, M., Hanas, R., Rewers, A., Sperling, M. A., & Codner, E. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12701 · Cited by 710
Hyponatremia: evaluating the correction factor for hyperglycemia
Hillier, T. A., Abbott, R. D., & Barrett, E. J. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00055-8 · Cited by 567
Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis
(2001) · New England Journal of Medicine · doi:10.1056/nejm200105173442014 · Cited by 533
Diabetic ketoacidosis and hyperglycemic hyperosmolar state
Wolfsdorf, J. I., Allgrove, J., Craig, M. E., Edge, J., Glaser, N., Jain, V., Lee, W. W., Mungai, L. N., Rosenbloom, A. L., Sperling, M. A., et al. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12165 · Cited by 371
Metadata
- Authors
- Katz, M. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1973-10-18
- Volume
- 289
- Issue
- 16
- Pages
- 843-844
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1970982784
- Cited by
- 524
- References
- 0
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- closed
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