The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Renin-Angiotensin System
Abstract
TIGERSTEDT and Bergman established a role for the kidney in blood-pressure regulation at the close of the 19th century. In a classic experiment, they produced hypertension in dogs by injecting a crude extract of kidney, which they called renin.1 Goldblatt called the attention of modern investigators to renal mechanisms of blood-pressure control by producing hypertension in the dog by clamping the renal artery.2 This experiment suggested the release of a pressor substance from the kidney when its circulation was impaired. Since that time, a cascade of enzymes, peptide and steroid hormones and cofactors belonging to the renin–angiotensin–aldosterone system have been . . .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
17-Hydroxylation deficiency in man
Biglieri, E. G., Herron, M. A., & Brust, N. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105499 · Cited by 561
ORAL CONTRACEPTIVES AND HYPERTENSION
Woods, J. (1967) · The Lancet · doi:10.1016/s0140-6736(67)90690-3 · Cited by 131
Cited by
The role of stroma in pancreatic cancer: Diagnostic and therapeutic implications
Erkan, M., Hausmann, S., Michalski, C. W., Fingerle, A. A., Dobritz, M., Kleeff, J., & Friess, H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.115 · Cited by 662
Drugs targeting the renin–angiotensin–aldosterone system
Zaman, M. A., Oparil, S., & Calhoun, D. A. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd873 · Cited by 439
Self-citationThe Renin-Angiotensin-Aldosterone System in Vascular Inflammation and Remodeling
Pacurari, M., Kafoury, R., Tchounwou, P. B., & Ndebele, K. (2014) · International Journal of Inflammation · doi:10.1155/2014/689360 · Cited by 374
Distribution of angiotensin II receptors in rat brain
Sirett, N. E., McLean, A. S., Bray, J. J., & Hubbard, J. I. (1977) · Brain Research · doi:10.1016/0006-8993(77)90296-7 · Cited by 302
The treatment of acute diarrhea in children. An historical and physiological perspective
Hirschhorn, N. (1980) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.3.637 · Cited by 289
Metadata
- Authors
- Oparil, S., & Haber, E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1974-08-22
- Volume
- 291
- Issue
- 8
- Pages
- 389-401
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1971092302
- Cited by
- 308
- References
- 2
- FWCI
- 15.40
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Renin-Angiotensin System. https://app.cochat.ai/papers/10.1056/nejm197408222910805
- The paper
- Oparil, S., & Haber, E. (1974). The Renin-Angiotensin System. New England Journal of Medicine. https://doi.org/10.1056/nejm197408222910805
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
