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Cited by 294

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Alternate-Day Prednisone: Leukocyte Kinetics and Susceptibility to Infections

Dale, David C., Fauci, Anthony S., Wolff, Sheldon M.·1974·New England Journal of Medicine

Abstract

The effects of alternate-day and daily prednisone on leukocyte kinetics were studied in 20 patients with inflammatory diseases to investigate the mechanisms of corticosteroid-induced susceptibility to infections. With daily prednisone, both neutrophil and monocyte inflammatory responses were significantly decreased. In patients on alternate-day prednisone, who were studied during the day on which prednisone was administered, neutrophilia and monocytopenia occurred, and cutaneous inflammatory responses of monocytes, but not of neutrophils, were significantly reduced. On the day of therapy of alternate-day prednisone and with daily therapy the half-life of labeled blood neutrophils was significantly prolonged, and the prolongation was proportional to the dose of the drug given. In contrast, in patients maintained on alternate-day prednisone therapy and studied on the day off drug, leukocyte counts, inflammatory responses and neutrophil half-life were normal. (N Engl J Med 291:1154–1158, 1974)

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Metadata

Authors
Dale, D. C., Fauci, A. S., & Wolff, S. M.
Venue
New England Journal of Medicine
Published
1974-11-28
Volume
291
Issue
22
Pages
1154-1158
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2341719812
Cited by
294
References
20
FWCI
21.35
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Alternate-Day Prednisone: Leukocyte Kinetics and Susceptibility to Infections. https://app.cochat.ai/papers/10.1056/nejm197411282912203
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Dale, D. C., Fauci, A. S., & Wolff, S. M. (1974). Alternate-Day Prednisone: Leukocyte Kinetics and Susceptibility to Infections. New England Journal of Medicine. https://doi.org/10.1056/nejm197411282912203

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.