The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Aerosol Polymyxin and Pneumonia in Seriously Ill Patients
Abstract
Pneumonia caused by Pseudomonas aeruginosa occurs frequently in critically ill patients and is associated with a mortality rate of 70 per cent. An aerosol of polymyxin B was administered (2.5 mg per kilogram per day) to the upper airways of 292 patients in a respiratory-surgical intensive-care unit during a seven-month period, in an attempt to prevent Ps. aeruginosa pneumonia. Although only one of the patients studied acquired pneumonia due to Ps. aeruginosa, 10 others acquired pneumonia caused by a polymysinx-resistant organism. Seven pneumonias were caused by organisms not frequently pathogenic to man (flavobacteria, serratia and Streptococcus faecalis). The mortality rate for acquired pneumonia in this study, 64 per cent, is greater than that in previous studies in which either no polymyxin or cyclic polymyxin therapy was used. Continuous use of polymyxin B aerosol appears to be a dangerous form of therapy.
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Citations
Cites
Changing Pharyngeal Bacterial Flora of Hospitalized Patients: Emergence of Gram-Negative Bacilli
Johanson, W. G., Pierce, A. K., & Sanford, J. P. (1969) · New England Journal of Medicine · doi:10.1056/nejm196911202812101 · Cited by 910
Cited by
The life and times of the Enterococcus
Murray, B. E. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.1.46 · Cited by 1,908
DUMOULIN, G. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90974-6 · Cited by 468
Ventilator-Associated Pneumonia
(2012) · SpringerReference · doi:10.1007/springerreference_225126 · Cited by 406
Unertl, K., Ruckdeschel, G., Selbmann, H. K., Jensen, U., Forst, H., Lenhart, F. P., & Peter, K. (1987) · Intensive Care Medicine · doi:10.1007/bf00254795 · Cited by 239
Metadata
- Authors
- Feeley, T. W., du Moulin, G. C., Hedley-Whyte, J., Bushnell, L. S., Gilbert, J. P., & Feingold, D. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1975-09-04
- Volume
- 293
- Issue
- 10
- Pages
- 471-475
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2329782666
- Cited by
- 261
- References
- 1
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Feeley, T. W., du Moulin, G. C., Hedley-Whyte, J., Bushnell, L. S., Gilbert, J. P., & Feingold, D. S. (1975). Aerosol Polymyxin and Pneumonia in Seriously Ill Patients. New England Journal of Medicine. https://doi.org/10.1056/nejm197509042931003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
