The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Randomized Clinical Trials: Perspectives on Some Recent Ideas
Abstract
In spite of the controversy over the role of randomized clinical trials in medical research, the rationale underlying such trials remains persuasive as compared to recent suggestions for alternative non-randomized studies such as those relying on the use of historical controls and adjustment technics. Others have suggested that recent statistical innovations for improving clinical trials, including adaptive allocation of treatment to patients and sequential stopping procedures, are underutilized. These innovations, though theoretically interesting, are not easily adapted to large-scale, complex medical trials in which there may be multiple end points and delayed response times. Ethical considerations suggest that randomized trials are more suitable than uncontrolled experimentation in protecting the interests of patients. Randomized clinical trials remain the most reliable method for evaluating the efficacy of therapies.
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Cites
Chi-Square Tests with One Degree of Freedom; Extensions of the Mantel-Haenszel Procedure
Mantel, N. (1963) · Journal of the American Statistical Association · doi:10.1080/01621459.1963.10500879 · Cited by 2,897
Pocock, S. J., & Simon, R. (1975) · Biometrics · doi:10.2307/2529712 · Cited by 2,350
Self-citationFlehinger, B. J. (1976) · Technometrics · doi:10.1080/00401706.1976.10489459 · Cited by 494
Play the Winner Rule and the Controlled Clinical Trial
Zelen, M. (1969) · Journal of the American Statistical Association · doi:10.1080/01621459.1969.10500959 · Cited by 451
Non-Randomized Controls in Cancer Clinical Trials
Gehan, E. A., & Freireich, E. J. (1974) · New England Journal of Medicine · doi:10.1056/nejm197401242900405 · Cited by 276
Allocation of Subjects in Medical Experiments
Weinstein, M. C. (1974) · New England Journal of Medicine · doi:10.1056/nejm197412122912405 · Cited by 190
The Bayesian Outlook and Its Application
Cornfield, J. (1969) · Biometrics · doi:10.2307/2528565 · Cited by 173
The Present Status of Shunts for Portal Hypertension in Cirrhosis
Grace, N. D., Muench, H., & Chalmers, T. C. (1966) · Gastroenterology · doi:10.1016/s0016-5085(66)80129-4 · Cited by 155
Controlled Studies in Clinical Cancer Research
Chalmers, T. C., Block, J. B., & Lee, S. (1972) · New England Journal of Medicine · doi:10.1056/nejm197207132870205 · Cited by 147
Statistical methods for the identification and use of prognostic factors
Armitage, P., & Gehan, E. A. (1974) · International Journal of Cancer · doi:10.1002/ijc.2910130104 · Cited by 138
Cited by
Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs
Concato, J., Shah, N., & Horwitz, R. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006223422507 · Cited by 3,563
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., & Smith, P. G. (1976) · British Journal of Cancer · doi:10.1038/bjc.1976.220 · Cited by 2,294
A method for assessing the quality of a randomized control trial
Chalmers, T. C., Smith, H., Blackburn, B., Silverman, B., Schroeder, B., Reitman, D., & Ambroz, A. (1981) · Controlled Clinical Trials · doi:10.1016/0197-2456(81)90056-8 · Cited by 1,349
Flay, B. R. (1986) · Preventive Medicine · doi:10.1016/0091-7435(86)90024-1 · Cited by 723
GAIL, M. H., WIEAND, S., & PIANTADOSI, S. (1984) · Biometrika · doi:10.1093/biomet/71.3.431 · Cited by 698
Self-citation
Metadata
- Authors
- Byar, D. P., Simon, R. M., Friedewald, W. T., Schlesselman, J. J., DeMets, D. L., Ellenberg, J. H., Gail, M. H., & Ware, J. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-07-08
- Volume
- 295
- Issue
- 2
- Pages
- 74-80
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2616762518
- Cited by
- 537
- References
- 16
- FWCI
- 28.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Byar, D. P., Simon, R. M., Friedewald, W. T., Schlesselman, J. J., DeMets, D. L., Ellenberg, J. H., Gail, M. H., & Ware, J. H. (1976). Randomized Clinical Trials: Perspectives on Some Recent Ideas. New England Journal of Medicine. https://doi.org/10.1056/nejm197607082950204
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
