The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Correction of Leukocyte Function in Chediak-Higashi Syndrome by Ascorbate
Abstract
Because ascorbate potentiates chemotaxis of normal leukocytes, we examined the effect of ascorbate on polymorphonuclear leukocytes from a patient with the Chediak-Higashi syndrome. Chemotactic migration was 104+/-16 leukocytes per 10 fields (mean+/-S.D.) initially and 258+/-44 (P less than 0.001) after ascorbate, as compared to 182+/-10 in controls. There was no bactericidal activity by 40 minutes in the patient's untreated leukocytes. After ascorbate bactericidal activity of patient and untreated control cells was the same. The addition of ascorbate reduced cAMP levels in the patient's cells from a mean of 34.5 pmoles per 10(7) polymorphonuclear leukocytes to 5.9, as compared to a control value of 3.1+/-1.4. The association of elevated cAMP and impaired function in the polymorphonuclear leukocytes of patients with the Chediak-Higashi syndrome may be related to abnormal microtubular assembly.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Quie, P. G., White, J. G., Holmes, B., & Good, R. A. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105568 · Cited by 906
Radioimmunoassay for Cyclic Nucleotides
Steiner, A. L., Pagliara, A. S., Chase, L. R., & Kipnis, D. M. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45622-6 · Cited by 572
Zurier, R. B., Weissmann, G., Hoffstein, S. T., Kammerman, S., & Tai, H. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107550 · Cited by 560
Stossel, T. P. (1974) · New England Journal of Medicine · doi:10.1056/nejm197403282901306 · Cited by 392
Abnormal Bactericidal, Metabolic, and Lysosomal Functions of Chediak-Higashi Syndrome Leukocytes
Root, R. K., Rosenthal, A. S., & Balestra, D. J. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106854 · Cited by 365
Mandell, G. L. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107963 · Cited by 318
Watanabe, A. M., & Besch, H. R. (1975) · Circulation Research · doi:10.1161/01.res.37.3.309 · Cited by 230
Self-citationBourne, H. R., Lehrer, R. I., Cline, M. J., & Melmon, K. L. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106564 · Cited by 170
Isolation and Properties of Phagocytic Vesicles from Polymorphonuclear Leukocytes
Stossel, T. P., Pollard, T. D., Mason, R. J., & Vaughan, M. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106664 · Cited by 158
Phagocytosis in Chronic Granulomatous Disease and the Chediak–Higashi Syndrome
Stossel, T. P., Root, R. K., & Vaughan, M. M. (1972) · New England Journal of Medicine · doi:10.1056/nejm197201202860302 · Cited by 139
Cited by
Carr, A., & Maggini, S. (2017) · Nutrients · doi:10.3390/nu9111211 · Cited by 2,035
A syndrome associating partial albinism and immunodeficiency
Griscelli, C., Durandy, A., Guy-Grand, D., Daguillard, F., Herzog, C., & Prunieras, M. (1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90858-6 · Cited by 386
A new immunodeficiency disorder in humans involving NK cells
Roder, J. C., Haliotis, T., Klein, M., Korec, S., Jett, J. R., Ortaldo, J., Heberman, R. B., Katz, P., & Fauci, A. S. (1980) · Nature · doi:10.1038/284553a0 · Cited by 277
Metadata
- Authors
- Boxer, L. A., Watanabe, A. M., Rister, M., Besch, H. R., Allen, J., & Baehner, R. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-11-04
- Volume
- 295
- Issue
- 19
- Pages
- 1041-1045
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2315608135
- Cited by
- 284
- References
- 14
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Correction of Leukocyte Function in Chediak-Higashi Syndrome by Ascorbate. https://app.cochat.ai/papers/10.1056/nejm197611042951904
- The paper
- Boxer, L. A., Watanabe, A. M., Rister, M., Besch, H. R., Allen, J., & Baehner, R. L. (1976). Correction of Leukocyte Function in Chediak-Higashi Syndrome by Ascorbate. New England Journal of Medicine. https://doi.org/10.1056/nejm197611042951904
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
