The DOI matches its Crossref record.
Enzymology of Cancer Cells: (Second of Two Parts)
Abstract
Carbohydrate Metabolism — Imbalance in Cancer Cells (Fig. 5)Liver and hepatomas are freely permeable to glucose; thus, the activity and concentration of competing enzyme systems (in the presence of cofactors) determine the fate of the hexose. The catabolic pathway of glucose, glycolysis, is opposed by the synthetic pathway of glucose production, gluconeogenesis. The three key enzymes of glycolysis (glucokinase, phosphofructokinase and pyruvate kinase) are opposed by the four key gluconeogenic enzymes (glucose-6-phosphatase, fructose 1,6-diphosphatase [FDPase], phosphoenolpyruvate carboxykinase and pyruvate carboxylase). The concept of key enzymes was developed from observations that the rate and direction of the opposing pathways of . . .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The Biology of Cancer Invasion and Metastasis
(1978) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60648-x · Cited by 801
Imaging Prostate Cancer: A Multidisciplinary Perspective
Hricak, H., Choyke, P. L., Eberhardt, S. C., Leibel, S. A., & Scardino, P. T. (2007) · Radiology · doi:10.1148/radiol.2431030580 · Cited by 601
FDG Accumulation and Tumor Biology
Pauwels, E. K. J., Ribeiro, M. J., Stoot, J. H. M. B., McCready, V. R., Bourguignon, M., & Mazière, B. (1998) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(97)00226-6 · Cited by 366
Bar-Shalom, R., Valdivia, A. Y., & Blaufox, M. D. (2000) · Seminars in Nuclear Medicine · doi:10.1053/snuc.2000.7439 · Cited by 340
Bustamante, E., Morris, H. P., & Pedersen, P. L. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68900-3 · Cited by 314
Metadata
- Authors
- Weber, G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-03-10
- Volume
- 296
- Issue
- 10
- Pages
- 541-551
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2969240875
- Cited by
- 416
- References
- 0
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Enzymology of Cancer Cells: (Second of Two Parts). https://app.cochat.ai/papers/10.1056/nejm197703102961005
- The paper
- Weber, G. (1977). Enzymology of Cancer Cells: (Second of Two Parts). New England Journal of Medicine. https://doi.org/10.1056/nejm197703102961005
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
