The DOI matches its Crossref record.
Plasmapheresis and Immunosuppressive Drug Therapy in Myasthenia Gravis
Abstract
Plasmapheresis combined with prednisone and azathioprine therapy produced striking clinical improvement in five patients with myasthenia gravis who still had moderate to severe disability despite thymectomy, high-dose prednisone therapy and optimal doses of cholinesterase inhibitors. Serial determinations of titers of serum antibody toward the acetylcholine receptor demonstrated a fall to 21 +/- 5 per cent (mean +/- S.D.) of the original levels concurrently with the patients' increasing strength. Clinically improved patients maintained lowered titers, whereas clinical relapses were associated with a rebound in titer. Our results suggest that plasmapheresis will find a place in the management of patients with myasthenia gravis, and they implicate antibodies to acetylcholine receptor as a pathogenic factor in this disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment
Pelosof, L. C., & Gerber, D. E. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0099 · Cited by 773
Lifetime course of myasthenia gravis
Grob, D., Brunner, N., Namba, T., & Pagala, M. (2008) · Muscle & Nerve · doi:10.1002/mus.20950 · Cited by 733
Pendergraft, W. F., Preston, G. A., Shah, R. R., Tropsha, A., Carter, C. W., Jennette, J. C., & Falk, R. J. (2004) · Nature Medicine · doi:10.1038/nm968 · Cited by 379
PLASMAPHERESIS IN TREATMENT OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I ASSOCIATED MYELOPATHY
Matsuo, H., Tsujihata, M., Satoh, A., Shirabe, S., Nakamura, T., Kinoshita, I., Tomita, I., Shibayama, K., & Nagataki, S. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90525-9 · Cited by 55
Metadata
- Authors
- Dau, P. C., Lindstrom, J. M., Cassel, C. K., Denys, E. H., Shev, E. E., & Spitler, L. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-11-24
- Volume
- 297
- Issue
- 21
- Pages
- 1134-1140
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2054196862
- Cited by
- 402
- References
- 0
- FWCI
- 35.34
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Plasmapheresis and Immunosuppressive Drug Therapy in Myasthenia Gravis. https://app.cochat.ai/papers/10.1056/nejm197711242972102
- The paper
- Dau, P. C., Lindstrom, J. M., Cassel, C. K., Denys, E. H., Shev, E. E., & Spitler, L. E. (1977). Plasmapheresis and Immunosuppressive Drug Therapy in Myasthenia Gravis. New England Journal of Medicine. https://doi.org/10.1056/nejm197711242972102
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
