The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Aspirin Prophylaxis of Venous Thromboembolism after Total Hip Replacement
Abstract
We assessed aspirin prophylaxis against venous thromboembolism in a prospective, controlled, double-blind study of patients over 40 years of age, who had undergone total hip replacement. Radiographic phlebography was the diagnostic end point. Thromboembolism developed in 11 of 44 patients receiving aspirin, as compared to 23 of 51 receiving the placebo (P less than 0.03). Unexpectedly, this protection was limited to men. In four of 23 men on aspirin thrombi developed, as compared to 14 of 25 receiving placebo (P less than 0.01). Corresponding figures for women were seven of 21 versus nine of 26. Review of a similar group of patients receiving aspirin revealed significantly greater protection (P less than 0.03) in men (three of 15) than in women (15 of 27). These data establish statistically significant prophylaxis in men over the age of 40 by 600 mg of aspirin given twice daily. The absence of a protective effect in women remains unexplained.
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Citations
Cites
Some Methods for Strengthening the Common χ 2 Tests
Cochran, W. G. (1954) · Biometrics · doi:10.2307/3001616 · Cited by 3,718
Cited by
Kahn (2012) · doi:10.1378/chest.11-2296 · Cited by 2,693
Collins, R., Scrimgeour, A., Yusuf, S., & Peto, R. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805053181805 · Cited by 1,314
Aspirin, Sulfinpyrazone, or Both in Unstable Angina: Results of a Canadian Multicenter Trial
Cairns, J. A., Gent, M., Singer, J., Finnie, K. J., Froggatt, G. M., Holder, D. A., Jablonsky, G., Kostuk, W. J., Melendez, L. J., Myers, M. G., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511283132201 · Cited by 1,120
Prevention of venous thrombosis and pulmonary embolism
Kakkar, V. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90116-i · Cited by 310
Metadata
- Authors
- Harris, W. H., Salzman, E. W., Athanasoulis, C. A., Waltman, A. C., & DeSanctis, R. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-12-08
- Volume
- 297
- Issue
- 23
- Pages
- 1246-1249
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2336435715
- Cited by
- 344
- References
- 1
- FWCI
- 34.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Aspirin Prophylaxis of Venous Thromboembolism after Total Hip Replacement. https://app.cochat.ai/papers/10.1056/nejm197712082972302
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- Harris, W. H., Salzman, E. W., Athanasoulis, C. A., Waltman, A. C., & DeSanctis, R. W. (1977). Aspirin Prophylaxis of Venous Thromboembolism after Total Hip Replacement. New England Journal of Medicine. https://doi.org/10.1056/nejm197712082972302
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
