The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Superiority of Demeclocycline over Lithium in the Treatment of Chronic Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Abstract
We evaluated demeclocycline and lithium therapy in 10 patients with the syndrome of inappropriate secretion of antidiuretic hormone. Despite severe water restriction, all patients had hyponatremia (mean +/- S.E.M. serum sodium of 122 +/- 1.1 meq per liter) and elevated urine osmolality (744 +/- 59 mOsm per kilogram) before treatment. Demeclocycline (600 to 1200 mg daily) restored serum sodium concentration to 139 +/- 1.1 meq per liter within five to 14 days, permitting unrestricted water intake in all patients. In three patients given lithium carbonate (900 mg daily) the serum sodium concentration, urine osmolality and urine volume were unchanged; since two patients had adverse central-nervous-system symptoms during lithium therapy, further study of this agent was abandoned. A patient with an unusual 22-year history of the syndrome was unresponsive to lithium, whereas long-term treatment with demeclocyline was markedly effective. Demeclocycline is superior to lithium in the treatment of the syndrome and may obviate the need for severe water restriction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The syndrome of inappropriate secretion of antidiuretic hormone
Bartter, F. C., & Schwartz, W. B. (1967) · The American Journal of Medicine · doi:10.1016/0002-9343(67)90096-4 · Cited by 1,276
Schwartz, W. B., Bennett, W., Curelop, S., & Bartter, F. C. (1957) · The American Journal of Medicine · doi:10.1016/0002-9343(57)90224-3 · Cited by 1,151
On the Mechanism of Lithium-Induced Diabetes Insipidus in Man and the Rat
Forrest, J. N., Cohen, A. D., Torretti, J., Himmelhoch, J. M., & Epstein, F. H. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107649 · Cited by 275
Self-citationHANTMAN, D., ROSSIER, B., ZOHLMAN, R., & SCHRIER, R. (1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-78-6-870 · Cited by 256
Lithium-induced nephrogenic diabetes insipidus: in vivo and in vitro studies
Singer, I., Rotenberg, D., & Puschett, J. B. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106900 · Cited by 179
Self-citationDemeclocycline-Induced Nephrogenic Diabetes Insipidus
Singer, I. I., & Rotenberg, D. (1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-79-5-679 · Cited by 149
Self-citationDemeclocycline Treatment in the Syndrome of Inappropriate Antidiuretic Hormone Secretion
CHERRILL, D. A., STOTE, R. M., BIRGE, J. R., & SINGER, I. (1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-83-5-654 · Cited by 119
Self-citation
Cited by
Clinical practice guideline on diagnosis and treatment of hyponatraemia
Spasovski, G., Vanholder, R., Allolio, B., Annane, D., Ball, S., Bichet, D., Decaux, G., Fenske, W., Hoorn, E., Ichai, C., et al. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3210-2 · Cited by 1,020
Clinical practice guideline on diagnosis and treatment of hyponatraemia
Spasovski, G., Vanholder, R., Allolio, B., Annane, D., Ball, S., Bichet, D., Decaux, G., Fenske, W., Hoorn, E. J., Ichai, C., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-1020 · Cited by 855
Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations
Verbalis, J. G., Goldsmith, S. R., Greenberg, A., Schrier, R. W., & Sterns, R. H. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.09.001 · Cited by 615
Jackman, D. M., & Johnson, B. E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67569-1 · Cited by 503
Causes of reversible nephrogenic diabetes insipidus: a systematic review
Garofeanu, C. G., Weir, M., Rosas-Arellano, M. P., Henson, G., Garg, A. X., & Clark, W. F. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.01.008 · Cited by 128
Metadata
- Authors
- Forrest, J. N., Cox, M., Hong, C., Morrison, G., Bia, M., & Singer, I.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1978-01-26
- Volume
- 298
- Issue
- 4
- Pages
- 173-177
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2319189417
- Cited by
- 304
- References
- 7
- FWCI
- 24.22
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Superiority of Demeclocycline over Lithium in the Treatment of Chronic Syndrome of Inappropriate Secretion of Antidiuretic Hormone. https://app.cochat.ai/papers/10.1056/nejm197801262980401
- The paper
- Forrest, J. N., Cox, M., Hong, C., Morrison, G., Bia, M., & Singer, I. (1978). Superiority of Demeclocycline over Lithium in the Treatment of Chronic Syndrome of Inappropriate Secretion of Antidiuretic Hormone. New England Journal of Medicine. https://doi.org/10.1056/nejm197801262980401
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
