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Prophylactic Doxycycline for Travelers' Diarrhea: Results of a Prospective Double-Blind Study of Peace Corps Volunteers in Kenya
Abstract
We performed a randomized double-blind study to determine the efficacy of doxycycline (100 mg daily) in preventing travelers' diarrhea among 39 Peace Corps volunteers during their first five weeks in Kenya. The volunteers took either doxycycline or placebo for three weeks and were observed for an additional two weeks. Nine of 21 taking placebo and one of 18 taking doxycycline had travelers' diarrhea during the treatment period (P = 0.012). The protection seemed to persist for at least one week after the drug was stopped. Enterotoxigenic Escherichia coli was the only pathogen isolated from the placebo group, but was not detected in persons taking doxycycline. None of these organisms were resistant to doxycycline or tetracycline, whereas resistance to tetracyclines and other antibiotics was common among the nonenterotoxigenic Esch. coli. We conclude that doxycycline effectively prevented most episodes of travelers' dirrhea.
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Citations
Cited by
Global Etiology of Travelers’ Diarrhea: Systematic Review from 1973 to the Present
Shah, N., DuPont, H. L., & Ramsey, D. J. (2009) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2009.80.609 · Cited by 326
Epidemiology of Travelers' Diarrhea and Relative Importance of Various Pathogens
Black, R. E. (1990) · Clinical Infectious Diseases · doi:10.1093/clinids/12.supplement_1.s73 · Cited by 305
New Developments in Traveler's Diarrhea.
(2011) · Europe PMC (PubMed Central) · Cited by 67
Metadata
- Authors
- Sack, D. A., Kaminsky, D. C., Sack, R. B., Itotia, J. N., Arthur, R. R., Kapikian, A. Z., Ørskov, F., & Ørskov, I.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1978-04-06
- Volume
- 298
- Issue
- 14
- Pages
- 758-763
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2340179564
- Cited by
- 215
- References
- 0
- FWCI
- 35.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Prophylactic Doxycycline for Travelers' Diarrhea: Results of a Prospective Double-Blind Study of Peace Corps Volunteers in Kenya. https://app.cochat.ai/papers/10.1056/nejm197804062981402
- The paper
- Sack, D. A., Kaminsky, D. C., Sack, R. B., Itotia, J. N., Arthur, R. R., Kapikian, A. Z., Ørskov, F., & Ørskov, I. (1978). Prophylactic Doxycycline for Travelers' Diarrhea: Results of a Prospective Double-Blind Study of Peace Corps Volunteers in Kenya. New England Journal of Medicine. https://doi.org/10.1056/nejm197804062981402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
