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Colonic Myoelectrical Activity in Irritable-Bowel Syndrome: Effect of Eating and Anticholinergics
Abstract
To determine the effect of a standard meal on colonic myoelectrical and motor activity in the irritable-bowel syndrome and to determine the effect of a single dose of an oral anticholinergic drug (clidinium bromide) on this response, we studied 10 patients. These patients showed a prolonged increase in both colonic spike (P less than 0.05) and motor activity (P less than 0.05) after eating as compared to normal subjects. Clidinium did not affect the frequency of colonic slow waves or the basal colonic spike and motor activity. However, the anticholinergic reduced the prolonged postprandial colonic spike and motor response in the patients and also reduced the postprandial increase in colonic contractions at 3 cycles per minute (P less than 0.05). These studies indicate that patients with the irritable-bowel syndrome show an abnormally prolonged post-prandial increase in colonic spike and motor activity. An anticholinergic drug reduces the duration and the magnitude of this abnormal colonic response.
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Citations
Cited by
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818
Ford, A. C., Sperber, A. D., Corsetti, M., & Camilleri, M. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31548-8 · Cited by 818
Pathophysiology of irritable bowel syndrome
Holtmann, G. J., Ford, A. C., & Talley, N. J. (2016) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30023-1 · Cited by 590
Increased mast cells in the irritable bowel syndrome
O’Sullivan, Clayton, Breslin, Harman, Bountra, Mclaren, & O’Morain (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00221.x · Cited by 480
The Irritable Bowel Syndrome: Review and a Graduated Multicomponent Treatment Approach
Drossman, D. A., & Thompson, W. G. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-12-1009 · Cited by 309
Metadata
- Authors
- Sullivan, M. A., Cohen, S., & Snape, W. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1978-04-20
- Volume
- 298
- Issue
- 16
- Pages
- 878-883
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2336091600
- Cited by
- 263
- References
- 0
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sullivan, M. A., Cohen, S., & Snape, W. J. (1978). Colonic Myoelectrical Activity in Irritable-Bowel Syndrome: Effect of Eating and Anticholinergics. New England Journal of Medicine. https://doi.org/10.1056/nejm197804202981604
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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