The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sickle-Cell Anemia: Molecular and Cellular Bases of Therapeutic Approaches: (First of Three Parts)
Abstract
THE term "molecular disease" was coined almost 30 years ago by Linus Pauling and his associates to describe their analysis of the abnormality in sickle-cell anemia.1 Since that time tremendous progress has been made in the understanding of the structure and function of this mutant hemoglobin molecule and the conditions under which it aggregates when deoxygenated to form a gel. Indeed, in the last decade, particularly in the last few years, there has been an explosive growth in knowledge of the structure of the gel of sickle hemoglobin and the mechanism of its formation. The exact relations among gelation, sickling . . .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sickle Cell Anemia, a Molecular Disease
Pauling, L., Itano, H. A., Singer, S. J., & Wells, I. C. (1949) · Science · doi:10.1126/science.110.2865.543 · Cited by 2,319
A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anæmia Hæmoglobin
INGRAM, V. M. (1956) · Nature · doi:10.1038/178792a0 · Cited by 896
Analysis of non-ideal behavior in concentrated hemoglobin solutions
Ross, P. D., & Minton, A. P. (1977) · Journal of Molecular Biology · doi:10.1016/s0022-2836(77)80191-5 · Cited by 275
Cited by
Riess, J. G. (2001) · Chemical Reviews · doi:10.1021/cr970143c · Cited by 773
Hemoglobin S gelation and sickle cell disease
Eaton, W., & Hofrichter, J. (1987) · Blood · doi:10.1182/blood.v70.5.1245.1245 · Cited by 425
Is there a threshold level of fetal hemoglobin that ameliorates morbidity in sickle cell anemia?
Powars, D., Weiss, J., Chan, L., & Schroeder, W. (1984) · Blood · doi:10.1182/blood.v63.4.921.921 · Cited by 314
Brittenham, G., Schechter, A., & Noguchi, C. (1985) · Blood · doi:10.1182/blood.v65.1.183.183 · Cited by 197
Self-citation
Metadata
- Authors
- Dean, J., & Schechter, A. N.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1978-10-05
- Volume
- 299
- Issue
- 14
- Pages
- 752-763
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2072295347
- Cited by
- 237
- References
- 3
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sickle-Cell Anemia: Molecular and Cellular Bases of Therapeutic Approaches: (First of Three Parts). https://app.cochat.ai/papers/10.1056/nejm197810052991405
- The paper
- Dean, J., & Schechter, A. N. (1978). Sickle-Cell Anemia: Molecular and Cellular Bases of Therapeutic Approaches: (First of Three Parts). New England Journal of Medicine. https://doi.org/10.1056/nejm197810052991405
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.