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Cited by 194

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Receptors, Antireceptor Antibodies and Mechanisms of Insulin Resistance

Bleich, Howard L., Boro, Emily S., Flier, Jeffrey S., Kahn, C. Ronald, Roth, Jesse·1979·New England Journal of Medicine

Abstract

THE first step in the action of insulin, as in the actions of all polypeptide hormones, is binding to receptor molecules on the plasma membrane of the cell.1 The receptor serves to recognize the specific hormone in the plasma, to bind it and then, as a hormone-receptor complex, to activate the cell. In this seminar, we briefly discuss the nature of peptide hormone receptors and their role in hormone action and then describe some recently identified clinical disorders, which have been clarified through studies of hormone-receptor interaction.Consistent with their role as mediators of the biologic effects of hormones is . . .

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Metadata

Authors
Bleich, H. L., Boro, E. S., Flier, J. S., Kahn, C. R., & Roth, J.
Venue
New England Journal of Medicine
Published
1979-02-22
Volume
300
Issue
8
Pages
413-419
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2077125601
Cited by
194
References
0
FWCI
7.66
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Receptors, Antireceptor Antibodies and Mechanisms of Insulin Resistance. https://app.cochat.ai/papers/10.1056/nejm197902223000808
The paper
Bleich, H. L., Boro, E. S., Flier, J. S., Kahn, C. R., & Roth, J. (1979). Receptors, Antireceptor Antibodies and Mechanisms of Insulin Resistance. New England Journal of Medicine. https://doi.org/10.1056/nejm197902223000808

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.